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Showing posts with label Medicine. Show all posts
Showing posts with label Medicine. Show all posts

Saturday, 30 November 2024

Cannabis and Infectious Diseases




'Antimicrobial resistance threatens the viability of modern medicine, which is largely dependent on the successful prevention and treatment of bacterial infections. Unfortunately, there are few new therapeutics in the clinical pipeline, particularly for Gram-negative bacteria. We now present a detailed evaluation of the antimicrobial activity of cannabidiol, the main non-psychoactive component of cannabis. We confirm previous reports of Gram-positive activity and expand the breadth of pathogens tested, including highly resistant Staphylococcus aureus, Streptococcus pneumoniae, and Clostridioides difficile. Our results demonstrate that cannabidiol has excellent activity against biofilms, little propensity to induce resistance, and topical in vivo efficacy. Multiple mode-of-action studies point to membrane disruption as cannabidiol’s primary mechanism. More importantly, we now report for the first time that cannabidiol can selectively kill a subset of Gram-negative bacteria that includes the ‘urgent threat’ pathogen Neisseria gonorrhoeae. Structure-activity relationship studies demonstrate the potential to advance cannabidiol analogs as a much-needed new class of antibiotics.'
 
 - Nature



Bhang the cooler is a febrifuge. Bhang acts on the fever not directly or physically as an ordinary medicine, but indirectly or spiritually by soothing the angry influences to whom the heats of fever are due. According to one account in the Ayurveda, fever is possession by the hot angry breath of the great gods Brahma, Vishnu, and Shiva. According to another passage in the Ayurveda, Shankar or Shiva, enraged by a slight from his father-in-law Daksha, breathed from his nostrils the eight fevers that wither mankind. If the fever-stricken performs the Vijaya abhishek, or bhang-pouring on the Ling of Shankar, the god is pleased, his breath cools, and the portion of his breath in the body of the fever-stricken ceases to inflame. The Kashikhanda Purana tells how at Benares, a Brahman, sore-smitten with fever, dreamed that he had poured bhang over the self-sprung Ling and was well. On waking he went to the Ling, worshipped, poured bhang and recovered. The fame of this cure brings to Benares sufferers from fever which no ordinary medicine can cure. The sufferers are laid in the temple and pour bhang over the Ling whose virtue has gained it the name Jvareshwar, the Fever-Lord. In Bombay many people sick of fever vow on recovery to pour bhang over a Ling. Besides as a cure for fever bhang has many medicinal virtues. It cools the heated blood, soothes the over-wakeful to sleep, gives beauty, and secures length of days. It cures dysentery and sunstroke, clears phlegm, quickens digestion, sharpens appetite, makes the tongue of the lisper plain, freshens the intellect, and gives alertness to the body and gaiety to the mind. Such are the useful and needful ends for which in his goodness the Almighty made bhang. In this praise of the hemp the Makhzan or great Greek-Arab work on drugs joins. 

 - Note to the Indian Hemp Drugs Commission of 1894-95 by J. M. Campbell , C.I.E., Collector of Land Revenue and Customs and Opium, Bombay, on the Religion of Hemp


Infectious diseases, also known as communicable diseases, are typically spread by three agents - bacteria, viruses, and fungi. Infectious diseases have existed from as far back as these agents have existed. When we humans descended from the chimpanzees, we carried along with us a host of these agents as well as our relationships with them. Many agents are beneficial for us, while some are benign, and others are harmful. There are possibly thousands of types of these agents residing in our bodies. We also come into contact with trillions of them in the course of our lives from our environment. I suspect that only a small fraction of these agents has been discovered by humans. The majority of them are unknown to us. These agents exist in a microcosm that is as vast as the macrocosm with its stars and galaxies and other heavenly bodies. There are theories that humans and other animals and plants are just vehicles through which these microscopic organisms rule the world. 

Evolution has equipped the human body with various defensive mechanisms against harmful microbes that assail it. The skin, the white blood corpuscles, digestive enzymes, our mechanisms of sweating, mucus formation, sneezing and control of body temperature are some of the natural defensive mechanisms that protect us from harmful microbes. Just as we evolve to protect ourselves from the harmful microbes, they themselves evolve to penetrate our defense mechanisms and enter our systems. The microbes mutate not only in the external environment where conditions are conducive for their development, they also mutate inside the bodies of different species of living beings. When they have gained sufficient characteristics, they are able to jump from one species to another through suitable carriers that form the bridge between species. There is a perpetual game of cops and robbers being played out beyond our senses. When a new mutation of a microbe or a microbe that we are unfamiliar with penetrates our defenses, it often overrides us and spreads throughout the body, as well as from person to person, sometimes wiping out large numbers of humans and other living beings in the process. Over time, a relative level of stability is reached where, in a sort of give-and-take, a certain number of living beings perish to the harmful microbes till the immune system adapts to the microbe and renders it relatively harmless. As stated, there are numerous microbes that are beneficial to us. It is said that a certain virus was responsible for enabling mammals to internally fertilize the egg with the sperm and develop the embryo in utero. Our digestive systems house numerous beneficial bacteria which comprise the microbiome. These work closely with the enzymes and hormones in our bodies to ensure that we stay healthy.

Typically, we see higher concentrations of microbes and the tendency to mutate easily in warm, humid conditions, such as the tropical regions, and so a higher prevalence of infectious diseases in these places. We also see higher concentrations and mutations in places where the density and proximity of carriers, such as humans and other animals, are higher. Often, the presence of unhygienic conditions, such as unhealthy food, water and sewage facilities, further increase the risk of increase of infectious diseases. Populations that live in close contact with infectious diseases develop immunity to them over a period of time. The spread of infectious diseases quite often happens when infected carriers move to new locations and come in contact with populations that have not been exposed to the infection-causing microbes. A classic example is the spread of infectious diseases from Europe to the Americas, resulting in the wiping out of large numbers of Native Indians through disease - numbers much larger than those decimated by the colonizers through war.

Natural calamities like famines, floods, fires, etc., also contribute significantly to the spread of infectious diseases primarily through the resulting damage to food, water and sewage facilities, and the inability to dispose dead human, animal and plant matter in time. 

In recent times, the human contribution to the spread of infectious diseases has increased greatly. For one thing, humans now live in greater concentrations in smaller areas. People from multiple geographic locations settle together and intermingle. There is great stress on food, water and waste disposal facilities. We also have the ravages of human-induced climate change that increasingly create events that are conducive to the growth and spread of infection-causing microbes. As if all this was not bad enough, humans engage in pursuits that increase the likelihood of mutation and spread of infectious disease. Among these pursuits, some of the primary ones are war, use of synthetic pharmaceutical medicines and chemical fertilizers and pesticides. War destroys a habitat's food, water and waste disposal systems and creates an environment conducive to the mutation and spread of infectious disease-causing microbes. The misuse, overuse and abuse of synthetic pharmaceutical drugs and chemical pesticides and fertilizers create mutations and microbial resistance to these synthetic compounds, besides wiping out beneficial microbes and lowering the immunity levels of all living beings that come in contact with it. It is estimated that around 8 million humans will die from anti-microbial resistance (AMR) by 2050. The number of other living beings is unknown, with potentially millions of species going completely extinct. War, the use of synthetic pharmaceuticals and chemical fertilizers and pesticides are driven by powerful industries that wish to profit from the sale of their products. These industries proactively work to create conditions that promote the increased sale of their products. Just the process of manufacturing these products - with the disposal of byproducts into the environment - creates conditions conducive to mutation and spread of infectious disease.

In the past few decades, pharma companies posted huge profits and growth based on their antibiotic drug sales, and they milked the antibiotic cow extensively. Over time humans and animals stopped responding to antibiotics. Even when pharma companies brought out new variations of these drugs by basically tweaking their compositions, they worked for a while but eventually became ineffective. What was happening was that the antibiotic was killing all bacteria, both good and bad, leaving the body with a depleted microbiome or bacterial ecosystem. People were losing their body's innate ability through their immune systems to fight bacterial infections. A vastly depleted microbiome, subjected to repeated wipe outs from frequent doses of antibiotics, was unable to restore itself to its original diversity, resulting in the human falling ill more frequently. To make things worse, bacteria mutated repeatedly to get around a particular type of antibiotic. What has happened now is that manufacture of antibiotics has hit a blank wall, in terms of how to introduce new variations to keep up with bacterial mutations. Even worse, combinations of various antibiotics now fail to work. Recently, new antibiotic-resistant bacterial varieties, called 'super bugs', have emerged which do not respond to conventional antibiotics. Many of these are being discovered in hospitals from where they spread rapidly causing complications and death. MRSA and XDR-TB are two such examples. Pharma companies, physicians and hospitals keep these outbreaks out of the public eye, as they face loss of credibility and business due to this. The problem of antibiotic resistance has reached such levels today that MSN reports - 'The problem of antibiotic resistance is described by the World Health Organisation as “one of the biggest threats to global health, food security, and development today”. Such infections already claim more than 35,000 lives each year in the US alone, and the UN warns this annual death toll could rise to 10 million globally if no solution is found.'

The World Health Organization (WHO) says '8 of the top 10 causes of death in 2021 in low-income countries were communicable diseases.' Lancet says that 'In 2019, 13·7 million people worldwide died from infectious syndromes, 5·2 million of which co-occurred with non-communicable diseases. 3 million of these deaths occurred in children under the age of 5 years. Globally, respiratory infections and bloodstream infections are the deadliest.'

Interestingly, WHO ranks Covid-19 as 2nd in the leading causes of death in 2021 globally. Covid-19 was a fake pandemic created by the pharmaceutical and medical industry, in conjunction with the petrochemical industry and autocratic leaders from countries like the US, UK, China, Russia and India, to boost the sales of pharmaceutical drugs, including opioids, and the sale of petrochemical-based medical equipment. The deaths attributed to Covid-19 are, in reality, deaths caused by the misuse and overuse of synthetic pharmaceutical drugs, including the so-called vaccines, developed by these countries. The result of this deceit on the global population resulted in a significant widening of the gap between the rich and the poor, specifically the wealth of the pharmaceutical, medical and petrochemical industries, and enabled autocratic leaders to tighten their control over the people of the world. We saw a significant rise in anti-microbial resistance (AMR) in all three areas - antibiotics, antivirals and antifungals. The misuse of steroids lead to an epidemic of mucormycosis, a deadly fungal disease. The production and use of all Covid-19 related synthetic medicines and medical equipment resulted in significant contamination to the environment, and drop in human immunity levels, thus further increasing the ability of deadly microbes to mutate and gain significant ground on other living beings. Millions of persons suffering from infectious and other diseases were denied treatment during the phase of this fake pandemic resulting in their death. Diseases like tuberculosis and HIV, which was being reasonably controlled, increased dramatically due to the denial of treatment. To add to that, the wealth sucked up by the rich upper classes of the world from the fake pandemic enabled Russia to go to war with Ukraine, and Israel to wage war in the Middle East with the support of weapons provided by the US. These wars significantly increased the spread of new mutations of deadly microbes in a climate that was conducive for them.

The human immune system (and those of other living beings) is key to survival against the constant onslaught of the microbes. Some of the basic requirements for the human immune system to be in top condition are adequate nutrition, sleep, rest and evacuation of waste toxins from the body. It is in these areas that cannabis is a key aid to the prevention of spread of infectious diseases among humans and other animals such as elephants, horses, cattle, camels and even the birds that we domesticate as poultry. Cannabis keeps the digestive system in a healthy condition, increasing appetite, possibly working with the microbiome to digest food, and enabling the elimination of toxins through perspiration, micturition and feces. Cannabis relieves fatigue and pain. It enables a person to sleep well and rest. In reduces stress and anxiety.

In the recent past, the role that cannabis plays in the prevention of infectious diseases has not been focused on to a large extent. This is, obviously, due to maligning of cannabis as an evil, harmful drug and its global prohibition. In the past, large numbers of the cannabis using communities had a strong belief in the infectious disease preventing abilities of cannabis. This belief arose from thousands of years of cannabis usage and the perceptions that this fostered. Native physicians in cannabis consuming communities were firm believers in its properties to prevent infections and prescribed cannabis for a range of diseases including malaria, cholera, dysentery, tetanus, gonorrhea, influenza, leprosy and the common cold. Most patients who used cannabis for the prevention of infectious diseases were from the poorest classes of society who could not afford any other type of medicine other than the freely available cannabis. Over time, with the advent of western medicine that arrived with the colonizers from Europe, cannabis as medicine for infectious diseases started to decline. This decline was primarily driven by the western physicians who were unfamiliar with cannabis on the one hand, and their desire to promote their own medicine on the other. The upper classes and castes of society joined hands with these western physicians and promoted western medicine at the cost of cannabis. Most of these medicines were expensive and consisted of compounds that were not as easily available as cannabis.  The extent of cannabis usage as medicine in 19th century India led the Indian Hemp Drugs Commission of 1894-95 which was set up by the British government to study the feasibility of regulation and prohibition of cannabis in India to state that 'Cannabis indica must be looked upon as one of the most important drugs of Indian Materia Medica.'  In the summary of medical uses of cannabis in its report, the Hemp Commission stated that 'In the class of specific infectious diseases, hemp drugs are stated to be used in hydrophobia, ague, remittent fever, cholera,"to relieve burning symptoms in phthisis," dysentery, erysipelas, and gonorrhœa. O'Shaughnessy more than 50 years ago used hemp resin with more or less success in hydrophobia and cholera. In the treatment of dysentery the resin has been found of much value by many European doctors, and excellent results have been obtained with it. In addition to the medicinal use of the drug for the treatment of cholera during epidemics, hemp drugs appear occasionally to be used as prophylactics, and for a similar purpose the use of the drugs is recommended in malarial areas to counteract the effects of "bad air and water." In both cases hemp drugs probably act as indirect prophylactics, stimulating the nervous system and allaying depression, thus serving much the same purpose as the popular use of alcoholic beverages by the lower classes in European countries during the prevalence of epidemics.' The Commission further stated that cannabis was extensively used as a febrifuge or preventive of infectious diseases by large numbers of the working classes and poorer sections of society. It stated in its summary that 'Febrifuge. 471. There is also a large body of evidence showing that hemp drugs, both as smoked and as drunk, are used as a febrifuge or preventive of the diseases common in malarious tracts or arising from the use of bad water. This is the justification alleged for the habitual use of these drugs in certain localities. Here, of course, the experience of the witnesses is more limited; but the evidence is very considerable. Labourers in malarious tracts and cultivators of wet and marshy lands, jungle tribes, and those who have to work or reside in jungle tracts, are among those who are said to use the drugs for these purposes. It is impossible also to shut the eyes to the evidence which often comes up unexpectedly, showing that respectable and intelligent people going on duty to such tracts, and sepoys sent on foreign service or garrisoning comparatively unhealthy districts, often take to these drugs for these purposes.'

This summarization of the use of cannabis as a prophylactic or febrifuge in the prevention of infectious diseases by the Hemp Commission was primarily derived from the vast evidence provided by individual witnesses to the Commission's questions regarding the medical uses of cannabis. In many cases, we see that most of the witnesses themselves were not convinced of the benefits of cannabis to prevent infectious diseases. Most witnesses to the Commission belonged to the Indian upper classes or were British citizens employed in administration in India. Both these sections of society were largely unfamiliar with the usage of cannabis and mostly relied on hearsay regarding how Indian native physicians and the people used cannabis. Most of these witnesses were themselves familiar with western medicine more than cannabis. Many witnesses were biased towards cannabis as bhang and prejudiced against cannabis as ganja or charas. This bias arises from a completely irrational belief that bhang and ganja were two different drugs with bhang being medicinal and ganja being harmful when, in fact, bhang was cannabis drunk (with the addition of milk, spices, nuts and other ingredients) whereas ganja was the cannabis plant smoked. The upper classes and castes consumed cannabis as bhang, primarily because they could afford the additional ingredients that went into making it, their religious sanctions that prohibited smoking, and because they had created the propaganda that ganja was an evil drug that only the lowest classes and castes smoked. The lower classes and castes smoked cannabis as ganja primarily because they could not afford the luxury of the additional time and ingredients that went into making bhang. The word 'bhang' is also seen as used by the later migrants into India from Central Asia to describe the cannabis plant, whereas the original inhabitants of India appear to have used the word 'ganja' to describe the plant. In this sense, the separation of cannabis into two different drugs - bhang and ganja - is a sort of discrimination against the original inhabitants of India by the later arrivals.

Let us look at a number of the witness statements to the Indian Hemp Drugs Commision of 1894-95. Mr. W. H. Grimley, Commissioner of Chota Nagpur, says, 'It is also taken as a medicine for the cure of diarrhœa, dysentery, asthma, and rheumatism in the form of a pill, the leaves being finely ground and mixed with a little water and black-pepper. Sometimes it is taken as a drink by diluting it with mere water. In a Sanskrit work ...Ganja in moderation is said to be a preventive of disease in malarious and unhealthy tracts.' Mr. F. H. Barrow, Magistrate and Collector of Bankura, says, 'All parts of the plants, the roots, the stem, the large leaves, the flowering tops and resin are all either alone, or mixed with other things, largely used for various diseases —gonorrhœa, diarrhœa,...tetanus...cholera...I have also seen it largely used in malarious districts to counteract exposure to malarious influences and to evade attacks of fever or malarial rheumatism and neuralgia. During epidemic or endemic appearance of cholera it is not only used as an effective medicine mixed with other things, but also alone as a prophylactic by those who are accustomed to it.' Mr. J. Kennedy, Magistrate and Collector of Murshidabad, says, 'Many use it occasionally as a febrifuge.' Mr. T. L. Jenkins, Magistrate and Collector of Dacca, says, 'Both ganja and bhang, but specially the latter, is used as a prophylactic for cholera.' Babu Gopal Chunder Mookerjee, Deputy Magistrate and Deputy Collector, Diamond Harbour, says, 'Yes; in malarious places bhang is used by some respectable people, ganja always by the low classes—moderately by the former, excessively by the latter, who use it to give staying power under severe exertion or to alleviate fatigue...Moderate use of bhang beneficial in cases of diarrhœa.' Babu Pran Kumar Das, Deputy Magistrate and Deputy Collector and Personal Assistant to the Commissioner of Burdwan, says, 'Ganja is used with cocoanut oil as a medicine for itch and fresh sores. Ganja is smoked for gonorrhœa, asthma, and hydrocele... It is also considered efficacious to withstand malarial effects and damp climate and exposure. My ganja-smoking servants had less malarious fever, and they said it alleviated pain.' Babu Gobind Chandra Basak, Deputy Magistrate and Deputy Collector, Brahmanbaria, Tippera District, says, 'Ganja is used as a preventive of disease in malarious tracts.' Babu Dina Nath De, Deputy Magistrate and Deputy Collector, Nadia, says, 'It is said, however, that ganja smokers do not suffer much from fever...It is said malarious diseases do not so much approach him.' Babu Ganendra Nath Pal, Kayasth, Deputy Magistrate and Deputy Collector, Naogaon, says, 'Its use acts as febrifuge and preventive of disease in malarious and unhealthy tracts...Among the consumers whose ordinary pursuits make them liable to exposure, work in water or colliery, use it as preventive. Under advice of native doctors, some people are seen to get rid of chronic fever by smoking ganja.' Babu Bhairab Nath Palit, Deputy Magistrate and Deputy Collector, Birbhum, says, 'It proves a prevention of disease in malarious and unhealthy tracts.' Babu Jogendro Nath Bandyopadhya, Brahmin, Deputy Magistrate and Deputy Collector, Jalpaiguri, says, 'Preventive of disease in malarious and unhealthy tracts.' Babu Manmohan Chakravarti, Deputy Magistrate and Deputy Collector, Jajpur, Cuttack, Orissa, says, 'In Puri and the adjoining saliferous tracts bhang is believed to prevent the formation of mucus and dysentery. ...moderate habitual use is believed to act as preventive of dysentery and diarrhœa. ..Taken with sugar or molasses; it removes stomachic spasms springing from acid-bile (amlapitta) humour, allays diarrhcea, puts a stop to cough and asthma, and prevents chronic dysentery rising from ambat. etc., etc., etc., etc., etc.' Babu Navakumar Chakravarti, Brahmin, Deputy Magistrate and Deputy Collector, Jangipur, Murshidabad, says, 'As a febrifuge or preventive of disease in malarious or unhealthy tracts;' Maulavi Abdus Samad, Deputy Magistrate and Deputy Collector, Purulia, Manbhum, says, 'Charas and ganja in moderation may serve as febrifuge or preventive of disease in malarious and unhealthy tracts.' Babu Surendranath Mozoomdar, Brahmin, Special Excise Deputy Collector, Monghyr, says, 'Ganja.—There is no general opinion, but North Gangetic people living in damp and malarious tracts think so. The people of Purnea around the Kosi banks use ganja largely for this purpose. I got fever once in the interior. On the next occasion on taking ganja I did not get any fever. This may be accidental, because I have seen people getting fever who take ganja.' Babu A. K. Ray, Sub-Divisional Magistrate, Bangaon, Jessore District, says, 'Ganja-smoking has been known to nip an attack of cholera in the bud. I have heard an old planter say that where no other medicine was available the moderate smoking of ganja cured no less than 60 per cent. of the men attacked with cholera.' Babu Kanti Bhushan Sen, Baidya, Special Excise Deputy Collector of Cuttack, says, 'As regards patti, its moderate habitual use is considered a febrifuge and antimalarious.' Babu Abhilas Chandra Mukerjee, Brahmin, Deputy Magistrate and Deputy Collector, on deputation as 2nd Inspector of Excise, Bengal, says, 'Ganja and bhang are prescribed on account of their medicinal properties by native doctors in the affections of ...diarrhœa...gonorrhœa (second stage), hysteria, and it is a household medicine for scabies. Ganja— (1) In scabies ganja is fried in mustard oil, and the oil is applied to the sores...Bhang— (1) In bowel-complaints and in strengthening and invigorating the system...In Mymensingh, where there are no karbirajes, wild bhang is used as a medicine for cholera by the people themselves. It is smashed and made into boluses. No other ingredients are mixed with it. A bolus of bhang weighs one to one and a half tolas....In the Dacca District people drink bhang as a preventive in the cholera season, or when cases of cholera appear. Bhang is smashed with water collected by washing atabchaul (rice)... In cholera seasons bhang is drunk in small quantities as a preventive against cholera.' Babu Roy Brahma Dutt, Kayasth, Excise Deputy Collector, Darbhanga, says, 'as a febrifuge and preventive of diseases in malarious and unhealthy tracts.' Babu Gour Das Bysack, Retired Deputy Collector, Calcutta, says, 'In malarious diseases a native kabiraj of repute tells me bhang has been prescribed in fever cases with success.' Babu Sir Chunder Soor, Satgope, 1st Assistant Supervisor of Ganja Cultivation, Naogaon, Rajshahi, says, 'as a febrifuge or preventive of disease in malarious and unhealthy tracts;... Persons suffering from malarious fever use ganja or its extract as a febrifuge.' Mr. R. L. Ward, District Superintendent of Police, Rajshahi, says, 'I certainly think that it is beneficial as a febribuge or preventive of disease in malarious tracts. I saw it used with marked effect in the Chittagong Hill Tracts and in Naogaon. It is also said that, owing to cultivation of ganja, there is much less malaria than in adjoining places.' Babu Jadub Chandra Chukerbutty, Brahmin, Civil and Sessions Judge, Kuch Behar, says, 'also as a febrifuge in malarious, damp, and unhealthy tracts.' Babu Sreenath Chatterjee, Brahmin, Cashier, Public Works Department, Darjeeling Division, says, 'Yes; it (ganja) is preventive of disease in malarious and unhealthy tracts of Bengal.' Surgeon-Major R. Cobb, Civil Surgeon and Superintendent, Lunatic Asylum, Dacca, says, 'I have found the moderate use of Cannabis indica very useful in the prevention and treatment of attacks of chronic dysentery. ..I have allowed patients to take the drug when they have been suffering from dysentery. Medicinally I use the "extract" of the pharmacopœia, and sometimes prescribe it as a preventive to patients liable to dysentery, though they may not have the disease upon them.' Rai Bahadur Kanny Loll Dey, C.I.E., late Chemical Examiner to the Government of Bengal, Calcutta, says, 'Hemp is acknowledged in British Pharmacopœia as a good febrifuge, and is reputed to be prophylactic of malaria in the steamy swamps of Lower Bengal.' Assistant Surgeon Upendra Nath Sen, Officiating Civil Medical Officer, Malda, says, 'ganja boiled in mustard oil is used in certain form of skin diseases, such as scabies, pruritus, etc.' Assistant Surgeon Norendra Nath Gupta, Baidya, in Civil Medical charge, Rangpur, says, 'as a preventive of disease in malarious and unhealthy districts;' Assistant Surgeon Chooney Lall Dass, Teacher of Medical Jurisprudence and Therapeutics, Medical School, Dacca, says, 'Many up-country people take ganja and bhang as a febrifuge.' Kailas Chundra Bose, Kayasth, Medical Practitioner, Calcutta, says, 'Extract of ganja sometimes acts as antiperiodic and febrifuge.' Kedareswar Acharjya, Brahmin, Medical Practitioner, Rampur Boalia, says, 'Ganja and bhang appear to exert some influence—a preventive of malarial fever. Ganja-smokers appear to be less liable to malarial attacks than other people. Sanyasis say that ganja-smoking protects them from the evil effects of bad water. This appears to be significant. As a febrifuge, I know one instance in which bhang stopped an attack of tertian ague which formerly resisted treatment.' Trailokya Nath Majumdar, Baidya, Medical Practitioner, Bankipur, says, 'but it is said that, in malarious districts, people using ganja are, comparatively speaking, more free from malarious poison.' Prasad Das Mallik, Subarnabanik, Medical Practitioner, Hughli, says, 'Ganja-smoking may act as a febrifuge in malarious and unhealthy tracts.' Nocoor Chander Banerji, Brahmin, Medical Practitioner, Bhagalpur, says, 'It might be used as a febrifuge or preventive of disease in malarious and unhealthy climates.' Guru Charan Ghosh, Medical Practitioner, Monghyr, says, 'Yes; as a febrifuge and preventive.' Annada Prasanna Ghatak, M.B., Private Medical Practitioner, Arrah, says, 'These drugs are not known to have any direct febrifuge or anti-malarious property, though Cannabis indica is sometimes used for its indirect effect in cases of chronic fever.' Rakhal Das Ghosh, Private Medical Practitioner, Calcutta, says, 'In countries like Bengal, Orissa and Assam, where poor inhabitants in their daily life are constantly exposed to all vicissitudes of temperature, now burning under a scorching sun, at the next moment being drenched by a heavy shower, it cannot be gainsaid that all sorts of tropical diseases are rampant. Malarious fevers, diarrhœa, dysentery, cholera, influenza, eruptive fevers, are all endemic, and it is a wonder how the people of such places could survive the dire ravages of these diseases. Though thousands of men succumb annually to these maladies, still a large percentage is left to prevent the countries being made deserts. How this large per cent. of people escape the jaws of death amidst such insanitary surroundings? The poor sufferers who cannot either afford to have medical help or medicines, or to travel miles to avail themselves of the benefit of the charitable dispensaries, are saved from their untimely deaths by the use of those drugs which are now the subjects of two Government Commissions. It is a fact beyond dispute, that those who moderately use ganja or opium can tide over or pull through an epidemic better than those who do not. Tetanus, rheumatism,  ague, diarrhœa, dysentery, cholera, dyspepsia and many painful disorders of the urinary or generative organs yield to the anodyne, soporific, antiperiodic, antispasmodic, and other properties of ganja or opium. Aided by these remedies the inhabitants combat for life and death.' Bijoya Ratna Sen, Kaviranjan, Kabiraj, Calcutta, says, 'I believe siddhi is preventive of disease in malarious or unhealthy tracts. Monks, peasants, cultivators, and native sailors, etc., use ganja and charas to obtain staying-power under exposure and to alleviate fatigue. This remark is applicable to moderate consumers only...The moderate use of siddhi is rather harmless. It increases the intellect of the man and does improve the health.' Gopeze Mohun Roy, Baidya, Kabiraj, Calcutta, says, 'In some malarious localities, bhang has been moderately and successfully used as a febrifuge or preventive of disease.' Binod Lal Sen, Baidya, Kaviraj, Calcutta, says, 'It is rather preventive of disease in malarious and unhealthy tracts, but not as a febrifuge.' Maharaja Girijanath Roy Bahadur, Kayasth, Zamindar, Dinajpur, says, 'An occasional consumer of ganja is found to become moderately habitual consumer when he goes to malarious and unhealthy tracts.' Rai Radha Govinda Rai, Sahib Bahadur, Kayasth, Zamindar, Dinajpur, says, 'It is, they say, febrifuge to prevent disease in malarious and unhealthy tracts.' Babu Hari Krishna Mazumdar, Baidya, Zamindar, Islampur, District Murshidabad, says, 'as a febrifuge in malarious tracts;' Babu Raghunandan Prasad Sinha, Brahman, Zamindar, District Muzaffarpur, says, 'The use of bhang prevents and cures many diseases, such as piles, indigestion, and fever, and also has refreshing effect.' Babu Surendra Nath Pal Chowdhury, Zamindar, Ranaghat, District Nadia, says, 'It is said to be a preventive of disease in malarious and unhealthy tracts.' Babu Rughu Nandan Prasadha, Zamindar, Patna, says, 'As a febrifuge or preventive of disease in malarious tract, it is well known that sometimes a draught of bhang taken a few hours before the "paroxysm in tertian quotidian" and other kinds of malarial fever cuts short the attack, and it is not uncommonly used for this purpose.' Babu Nundo Lal Gossain, Brahmin, Zamindar, Serampore, says, 'Moderate use of ganja and bhang is beneficial as giving staying power under severe exertion or exposure, as alleviating fatigue, and as febrifuge; they possess also medicinal virtues. Bhang is believed to be beneficial in cases of chronic diarrhœa.' M. Kazi Rayaz-ud-din Mahamed, Zamindar, Commilla, Tippera, says, 'Ganja is used as a preventive of disease in malarious tracts.' Mr. L. H. Mylne, Zamindar and Indigo-planter, Justice of the Peace, President of Independent Bench of Honorary Magistrates, Chairman of Jugdispur Municipality, District Shahabad, says, 'Occasionally used as a febrifuge.' Mr. John D. Gwilt, Tea Planter, Longview Company, Limited, Darjeeling, says, 'The people who consume them state they act as a food accessory; that they do give staying-powers and alleviate fatigue; that they are also of use in unhealthy tracts of country, and there is decidedly a certain amount of truth in these statements.' Babu Parameshwar Dan, Kshetrya, Pleader, Judge's Court, Vice- Chairman, District Board, Dinajpur, says, 'It is also used as a preventive in malarious and unhealthy tracts.' Babu Beprodas Banerjee, Brahman, Pleader, Newspaper Editor, and Chairman, Baraset Municipality, says, 'It is a remarkable fact that ganja smokers were free from attacks of fever when malaria appeared in Baraset, etc. In cases of diarrhœa bhang is used by all classes of the people and with effect.' Babu Nobo Gopal Bose Rai Chowdhoory, Kayasth, Talukdar and Judge's Court Pleader (late Munsiff of Nator), Memari, Burdwan District, says, 'also low classes, Bagdi, Hari, and Chandáls, use ganja as preventive of fever.' Babu Abinas Chandra Dass, M. A., B. L., Pleader, Judge's Court, Bankura, says, 'as a preventive of disease in malarious and unhealthy tracts.' Babu Anango Mohan Naha, Kayasth, Judge's Court Pleader, Comilla, Tippera District, says, 'In cholera epidemics I have seen lower classes of people use bhang as a preventive and also as medicine with success. Small number of low class people use bhang in epidemic cholera.' Babu Bhuvan Mohun Sanyal, Brahmin, Government Pleader, Purnea, says, 'I have often observed that ganja-smokers are generally free from malarious fever, From this I conclude that it is a febrifuge, but I don't think anybody uses it as such.' Babu Jadubans Sahai, Pleader and Vice-Chairman, Arrah Municipality, says, 'The use of these drugs is sometimes considered as a febrifuge in malarious or unhealthy districts, but I am not sure how far this belief is grounded on actual facts.' Babu Gowree Sunker Roy, Kayasth, Secretary, Cuttack Printing Company, Cuttack, says, 'Bhang is preserved by many as a household medicine for all sorts of bowel complaints and colic pain, and as a cooling beverage in the hot season. Indeed, some go so far as to say that the restriction of the sale of bhang by the Excise Department has deprived many of a ready cure in cases of bowel complaints and even cholera.' Babu Gurudayal Sinha, Kayasth, Honorary Magistrate, Municipal Commissioner and Secretary, Total Abstinence Society, Comilla, Tippera, says, 'Bhang is prescribed by native physicians as medicine in cases of dyspepsia, dysentery and diarrhœa, but the lower classes of people only use it.' Rai Bahadur Raj Kumar Sarvadhikari, Secretary, British Indian Association, Calcutta, says, 'Bhang is beneficial in cases of chronic diarrhœa;' Umagati Rat, Brahmin, Pleader, and Secretary to the Jalpaiguri Branch, Indian Association, says, 'I have seen many persons suffering from dysentery and bowel complaints using bhang under the directions of the kavirajes. Bhang is also used by the kavirajes in the preparation of medicines for dysentery, grihini (chronic dysentery) and diarrhoea. I had to use such medicines myself for some time for similar affections.' Babu Akshay Kumar Maitra, Secretary, Rajshahi Association, Pleader, Judge's Court, Member, Rajshahi District Board, Commissioner, Rampur Boalia Municipality, says, 'Sanyasis and mendicants of all denominations claim for ganja the peculiar virtue of preventing disease in malarious and unhealthy tracts, but I do not know how far this virtue actually resides in the drug. I have observed during my sojourn to the North-Western Provinces, Oudh and Rohilkhand that the people there daily take a small quantity of bhang as a cooling draught, and allege that such moderate daily consumption wards off an attack of diarrhœa which is induced by the excessive heat of summer.' Babu Nobin Chandra Sarkar, Kayasth, Wholesale and retail vendor of ganja and bhang, Barisal, says, 'A mixture of ganja with oil is used for itches and other skin diseases.' District Board, Monghyr (Sub-Committee), says, 'in instestinal disorders by native physicians; also very useful in dysentery. Ganja used as a preventive of the effects of damp and exposure to malaria and said to be very efficacious...Ganja is a good preventive of malarial disease.' Surgeon-Major H. C. Banerji, Civil Surgeon, Sylhet, says, 'It is said to be anti-malarial and antirheumatic; ..I am not prepared to say that ganja is anti-malarial, but as it is a nerve tonic I think it would be beneficial in cases of fever. I understood my informants to say that they took ganja when they got rheumatic pains and that it relieved them. I was told this by habitual smokers, and also by people who never smoked except to relieve pain. A native practitioner showed me two cases which he said had been dropsical, and had been under treatment by various remedies for some time. Finally he administered the tincture of Cannabis internally and ordered the patients to smoke ganja. When I saw the patients they were dried up and there were no dropsical appearances. On the contrary, they appeared atrophied. The practitioner was a failed student of the Medical College. He is a good practitioner, and has been working in Sylhet for some seventeen years, so that I place reliance on his statements. I did believe that the cure was due to this, and therefore put it down. I did not enquire what the dropsy was due to. I have heard that effusion into cavities does undergo spontaneous absorption, but I have no experience.' Prosunno Koomar Das, Baidya, Medical Practitioner, Silchar, Cachar, says, 'Are anti-malarious.' Colonel M. M. Bowie, Commissioner, Nerbudda Division, says, 'The belief is also very prevalent that it is of use to ward off malaria. The people tell me that they use it when they have to go to jungle tracts where the water is bad.' Mr. B. Robertson, Deputy Commissioner, Nimar, says, 'is useful as a febrifuge. ...The use of ganja as a febrifuge is distinctly believed in in this district.' Trimbak Rao Sathe, Extra Assistant Commissioner, and Diwan of the Sonepur State, says, 'The moderate, occasional consumers take it as a febrifuge or preventive of disease, when they go to malarious and unhealthy tracts, or when cholera epidemic or such other disease breaks out. In the latter case persons are persuaded to take the drug (ganja or bhang)...I have not tasted ganja myself; but I know the people think it prevents cholera. They say they use it ; but I do not know myself.' Batuk Bharthy, Superintendent of Kalahandi State, says, 'Ganja is considered as preventive of diseases in malarious and unhealthy climates.' Alam Chand, Superintendent, Bastar State, says, 'Yes, it is used in the treatment of dysentery. diarrhoea, etc.,' Chintamani Nand Vidhya Bhushana, Uria Brahmin, late Tahsildar, Sonepur, Sambalpur, says, 'It cures dysentery, and is to some extent preventive of cholera if used with some medicine. It has been observed that when cholera prevails in any place, many of the people residing therein generally take ganja with a view to puss off fear.' Anandi Pershad, Excise Daroga, Hoshangabad, says, 'Its use saves a man from falling sick when the climate is not good.' Munshi Mahomed Ghouse, Extra Assistant Conservator of Forests, Raipur, says, 'It is a common belief that ganja and bhang are beneficial in their effects. The former is said to be preventive of diseases in malarious and unhealthy places.' Surgeon-Major H. K. Mckay, Civil Surgeon, Nagpur, says, 'Bhang is used as a febrifuge pretty generally.' Surgeon-Major W. A. Quayle, Civil Surgeon, Nimar, says, 'I am also told that consumers working in or travelling through malarious jungles are less liable to attacks of fever.' Apothecary J. Prentie, Civil Surgeon, Bhandara, says, 'Both used during prevalence of cholera to some extent by nervous and timid people.' Gangadharrao Madho Chitnavis, Honorary Magistrate, Nagpur, says, 'It also acts as a febrifuge or preventive of disease in malarious and unhealthy tracts. Pilgrims and wanderers generally use it for these purposes.' Mir Imdad Ali, Honorary Magistrate, Damoh, says, 'Bhang is sometimes taken in fever before the expected return to prevent it returning.' Kapur Chand, Honorary Magistrate and Gumasta, Raipur, says, 'Both are useful as febrifuges. ..Bhang is a cure for cholera if given in time. It is used by waids of Marwad. I gave it to my child.' Hari Har Singh, Zamindar and Honorary Magistrate, Sambalpur District, says, 'We hear that in unhealthy tracts ganja is used in sufficient quantities.' Pandit Narayan Rao Gobind, Brahmin, Zamindar, Hurda, says, 'As a febrifuge or preventive of disease in malarious and unhealthy tracts.' Rao Sahib Balwantrao Govindrao Bhuskute, Brahmin, Jagirdar of Timborni, Barhanpar, Nimar District, says, 'It also acts as a febrifuge or preventive of disease in malarious and unhealthy tracts.' Rev. I. Jacob, Church of England Missionary, Chairman, District Council, etc., Chanda, says, ' Ganja is used as a preventive of maladies arising from impure water in malarious and unhealthy districts. Hence its extensive use in the Zamindaris and Feudatory States.' Onkar Das, Agarwalla Bania, Mahajan, Seoni-Chapara, says, 'Also ganja certainly enables the Gond to live under conditions of bad water, and malarial exhalations, which would soon kill a non-smoker of ganja.' Husen Khan, Pathan, Abkari Contractor, Seoni-Chapara, says, 'The moderate consumption of ganja is certainly beneficial to the labouring classes and to those who are exposed to malaria...The Gonds and cultivating classes in malarial tracts and all weathers could not get on without ganja ; it enables them to live under conditions of water-supply and decaying vegetation which would kill others.' Mr. R. Sewell, Collector of Bellary, says, 'My own opinion is that it has a distinct effect as a febrifuge in feverish tracts, and that natives often use it for that purpose. For instance, the people in the Godavari district, which is feverish, are great consumers of tobacco. In the streets of Coconada the smell of tobacco-smoke is everywhere. Children are made to smoke, and the reason probably is that the natives believed smoking to be a good preventive against fever. I think they consume these drugs for the same reason, very often.' Mr. J. Thomson, Collector of Chingleput, says, 'As a febrifuge in ease of fevers arising from, cold.' Mr. G. S. Forbes, Collector of Tinnevelly, says, 'Ganja is prescribed by native physicians for ...tetanus, hydrophobia, cholera, diarrhœa, and dysentery.' Mr. L. C. Miller, Acting Collector of Trichinopoly, says, 'It is said to prevent illness due to change of water.' Mr. K. C. Manavedan Raja, Collector, Anantapur, says, 'It is said that these drugs are prepared as a stimulant for asthma, fever, dysentery, and externally for colic.' Mr. H. Campbell, Acting Sub-Collector, Guntoor, says, 'it is said of smoking ganja that it serves as a prophy-latic against diseases contracted in malarious climates.' Mr. J. H. Merriman, Deputy Commissioner of Salt and Abkari, Central Division, says, 'Majum is said to assist digestion, to give staying-power, and to act as febrifuge. In diarrhœa it is also said to be used. I refer to moderate use.' W. Venkatappiah Pantulu Garu, Brahmin, Deputy Collector, Chatrapur, Ganjam, says, 'in the prevention of cough and other complaints due to change of water and climate.' M. R. R. Dewan Bahadur S. Venkata Ramadas Naidu, Deputy Collector, Godavari, says, 'Ganja is considered a prophylactic, but bhang is a febrifuge and is used in cases of fever and ague. .. People in malarious places use the drugs in this manner.' Mr. W. E. Ganapathy, Retired Deputy Collector, Palamcottah, Tinnevelly, says, 'for preventing malarious diseases.' G. Jagannayakulu, Acting Tahsildar, Gooty, says, 'Bhang and ganja are used as a preventive of disease in malarious and unhealthy tracts.' A. Katchapeswara Iyer, Brahmin, Stationary Sub-Magistrate, Cuddapah Taluk, says, 'I have ascertained from ganja consumers as well as native doctors that the use of ganja acts as a prophylactic against fever.' K. Rama Kristna Bramham, Brahmin, Stationary Sub-Magistrate, Kudlighi, Bellary District, says, 'very moderate use will act as a prophylactic to certain diseases, especially fevers, cold, etc.' M. Seshachala Naidu, Baliya, Pensioned Tahsildar, Vellore, says, 'Purnathy is also used as a preventive of disease in malarious tracts. I refer to the moderate occasional use by people travelling in malarious tracts.' N. Soondramiah, Brahmin, Deputy Tahsildar, Ootacamund, says, 'Many of the Bairagis and fakirs use ganja moderately to alleviate fatigue or to subside hunger, and the hill tribes of various tracts use it as a preventive of disease.' P. Lakshminarayana, Brahmin, Manager of Court of Wards' Estate, Nuzvid, says, 'Smoking ganja prevents any change coming over the system of a man by frequent change of climate and water used for drinking.' Mr. R. W. Morgan, Deputy Conservator of Forests, Ootacamund, Nilgiris, says, 'The smoke of bhang is probably a germicide and disinfectant, and this may act as a preventive of disease.' Surgeon-Major John Lancaster, District Surgeon, North Arcot, says, 'in tetanus, in malarious dysentery.' Surgeon-Major K. C. Sanjana, Parsi, District Surgeon, Tinnevelly, says, 'Ganja is prescribed by native doctors in the form of halwa ...for ...tetanus...cholera, diarrhœa and dysentery.' Civil Apothecary T. M. Cheriyan, Manantoddy, says, 'Yes, it is used by some native doctors in diarrhœa, colic, cholera, etc.' Dr. Arthur Wells, Medical Officer, Chicacole, Ganjam District, says, 'A preparation of the hemp plant, called halwa, is used in the treatment of dysentery, chronic cough, colic, etc., by native doctors. ...Supposed to be preventive of disease in malarious and unhealthy tracts. It is generally used in these instances by the lower classes and by moderate habitual users.' K. Jagannadham Naidu, Medical Officer, Parlakimedi, Ganjam District, says, 'Those living in malarial places smoke ganja under the belief that it prevents malarial fever.' Assistant Surgeon Saldhana, Salem, says, 'is reputed to have the power of preventing disease in malarious and other unhealthy tracts; so that habituals can travel from place to place of different climatic and other conditions with impunity from such trivial complaints as are incidental to such a fugitive life.' Hospital Assistant T. Ranganaya Kulu Naidoo, Rajahmundry, Godavari District, says, 'Yes, native doctors prescribe for dysentery, chronic diarrhoœa, and cholera, mixing with poppies, pepper and sugar. Headaches, tetanus, and menorrhagia...Yes. It is considered as a preventive when travelled in malarious tracts.' Hospital Assistant I. Parthasarathy ChettyA, Penukonda, Anantapur District, says, 'Yes, as febrifuge against malaria.' Mirza Davood Beg, Pensioned Hospital Assistant, Trichinopoly, says, 'it acts as a prophylactic measure for some time in malarious tract.' H. S. A. M. Munjumiah, Native Medical Practitioner, Cuddapah, says, 'as a preventive of disease in malarious and unhealthy tracts. Several native sepoys who are tossed about from one place to another use ganja for smoking to prevent fevers, etc. ...On several occasions I have prescribed the use of ganja as a means of digesting food and with other medicines preventing malarious fevers, asthma, abdominal irregularities of some kind.' Sagi Rama Sastry, Brahmin, Inamdar and Native Doctor, Rajahmundry, Godavari District, says, 'By a moderate use of the drug, the consumer feels pleasant and gets rid of cough, if he has any.' Mr. W. Taylor, Chairman, Municipal Council, Parlakimedi, Ganjam District, says, 'The moderate use of these drugs is considered a prophylactic against malarial fevers, and other diseases incidental to life in the Indian jungles.' Rev. H. F. Laflamme, Canadian Baptist Mission, Yellamanchili, Vizagapatam, says, 'It is the fact that the drugs are more used in malarious tracts, and probably the users do believe in their protective effects against fever;' Rev. J. Heinrichs, Missionary, Vinukunda, Kistna District, says, 'In malarious and unhealthy places it is supposed to prevent disease. Most of the consumers are seen among invalid sepoys who practised ganja smoking when they were engaged on foreign expeditions.'  N. Kothundaramayya, Brahmin, Editor of "Suneeti" Rajahmundry, Godavari District, says, 'Bairagis and sanyasis use the drug with a belief that they will not be subject, in their wanderings from the Himalayas to Rameswaram (Cape Comorin), to the bad effects of different climates and waters.' Hon'ble A. Sabapathy Moodelliar, Rai Bahadur, Merchant, Bellary, says, 'Decidedly it is a preventive of disease in malarious and unhealthy tracts.' Mirza Mehdy Ispahani, Merchant, Madras, says, 'It does prevent disease in malarious and unhealthy tracts.' Appala Narassiah Chetty, Vaisya, Merchant, Berhampore, says, 'Ganja is used in pills as a febrifuge in malarious and unhealthy tracts.' Mokhalingam Appanna, Ganja Vendor, Coconada, says, 'The moderate use of ganja is beneficial, as it removes the effects caused by a change of climate.' Mulagula Kondiah, Goldsmith, Rajahmundry, says, 'It serves as a preventive of malarious fevers, etc.' Samdasu Bavaji, Brahmin, Priest in the Matt of Sri Jagannadha Swamy, Rajahmundry, says, 'May serve as a febrifuge or preventive of disease in malarious and unhealthy tracts.' Mr. E. J. Ebden, Collector, Ahmednagar, says, 'Popular opinion is that ganja smokers escape fever and many other complaints.' Mr. C. G. Dodgson, Assistant Magistrate and Collector, Khandesh, says, 'Ganja is sometimes used by native doctors as a febrifuge and sedative in cases of fever and asthma...It is also used by them to check diarrhœa.' Rao Bahadur Narayan Ganesh Deshpande, Brahmin, Deputy Collector, Belgaum, says, 'It is said that ganja smoking and bhang eating serve to prevent fever more or less.' Rao Bahadur Bhimbhai Kirpa Ram, Brahmin, Huzur Deputy Collector of Surat, says, 'it is a febrifuge in malarious districts.' Rao Bahadur Vyankatesh Bapuji Wadekar, Deputy Collector, Ahmednagar, says, 'It destroys the bad effects resulting from unwholesome water.' Khan Bahadur Dadabhai Deenshah, Parsi, Huzur Deputy Collector and Magistrate, 1st Class, Kaira, says, 'Bhang is drunk in fever cases by some persons, though not a large number, with a view to keep down the temperature of the body. ..To ward off the effects of bad water -supply, ganja is considered by all smokers to be a sovereign remedy. Travellers in tracts where the water-supply is not good use it, according to their opinion, with beneficial results, as far as the effects of bad water are concerned.' Rao Bahadur Sitaram Damodhar, Huzur Deputy Collector, Khandesh, says, 'By native doctors it is used as specific for dysentery...It is also used in cholera cases.' Khan Bhadur Ratanji Erdalji Kanga, Parsi, Deputy Collector and Magistrate, Dharwar, says, 'It is a popular belief here that the use of ganja in malarious and unhealthy tracts is a febrifuge and preventive of disease.' Rao Bahadur Rango Ramchandra Bhardi, Deputy Collector and Native Assistant to the Commissioner, Poona, Central Division, says, 'Persons who actually consume the drug say that the moderate use of it is beneficial in its effects as preventive of disease in malarious and unhealthy tracts;' Rao Bahadur Rajaram Mule, Deshastha Brahmin, Administrator of Jath, in Southern Mahratta Country, says, 'It is a popular belief that smoking of ganja is preventive of disease in, malarious and unhealthy tracts.' Balkrishna Narayan Vaidhya, Parbhu, State Karbhari of Sangli, says, 'acts as febrifuge or preventive of disease in malarious and unhealthy tracts. Most of the gosains, bairagis, and fakirs use ganja as a febrifuge or preventive of disease in malarious and unhealthy tracts.' Dadabhai Burjorjee Guzder, Parsi, District Abkari Inspector, Ahmednagar, says, 'It destroys the bad effects resulting from bad water in malarious and unhealthy tracts.' Yashvant Nilkanth, Patana Prabhu, Superintendent, Office of Survey Commissioner, and Director of Land Records and Agriculture, Bombay, says, 'It is sometimes used as an alleged preventive of disease in malarious and unhealthy tracts, ganja smoking for this purpose being not quite unknown in the lower ranks of survey subordinates, whose work causes much exposure to unaccustomed climate.' Mr. G. P. Millet, Divisional Forest Officer, West Thana, Thana, says, 'Would have a beneficial tendency in a malarious climate.' Mr. H. Kennedy, District Superintendent of Police, Ahmednagar, says, 'Both ganja and bhang are said to be recommended by native doctors for diarrhœa, dysentery, and piles.' Mr. J. E. Down, Districts Superintendent of Police, Satara, says, 'Is sometimes prescribed by native doctors as a febrifuge and for dysentery;' Mr. F. T. V. Austin, District Superintendent of Police, Surat, says, 'The moderate use of ganja is supposed to be beneficial in the prevention of fever and in reducing the ill-effects likely to follow the habitual use of bad water; while from bhang a cooling drink is prepared which is said to be very beneficial in intermittent fever. Bhang and ganja are so used by the poorer classes, both habitually as also occasionally.' Khan Bahadur Nanbhoy Cowasji, Parsi, City Police Inspector, Surat, says, 'Ganja is not used as a febrifuge, but bhang is sometimes used in cases of fever by some persons... Persons in well-to-do circumstances do not, except in some cases when travelling, smoke ganja to counteract the effects of bad water.' Surgeon-Major D. C. Davidson, Acting Civil Surgeon, and Superintendent of the Jail and Lunatic Asylum, Dharwar, says, 'It is used extensively by the people themselves in malarial fever...diarrhœa...' Surgeon-Major K. R. Kirtikar, Civil Surgeon, Thana, and Medical Officer, Thana Depot and District Jail, says, 'The old standard Sanskrit writers, who are generally studied by native doctors, recommend Cannabis indica, or the hemp plant and its products, for the following diseases :— ...diarrhœa...and quartan fevers. .. of ganja gives relief in chest complaints, such as asthma, by acting as an antispasmodic, and reduces the excessive discharge of phlegm (mucous and muco-purulent expectoration)....I know of no practical use of this drug in fevers, either as a preventive or curative agent ; but it is recommended by native writers for quartan fevers, as already stated in answer to question No. 40.' Rao Saheb Bhicajee Amroot Chobhe, Brahmin, Assistant Surgeon, Poona City, says, 'European doctors prescribe extract and tincture of ganja in cases of diarrhœa, dysentery,...tetanus, etc. Native Vaidyas prescribe ganja and its preparations in some of the above maladies.' Khan Bahadur Dossabroy Pestonjee, Parsi, Assistant Surgeon, Parakh Dispensary, Surat, and Honorary Assistant Surgeon to His Excellency the Viceroy, says, 'It is said to be a febrifuge in malarious districts.' Rao Bahadur Thakordas Kikabhai, Bania, Assistant Surgeon, Wadhwan Civil Station, Kathiawar, says, 'I have no personal experience of its beneficial effects as a preventive of disease in malarious and unhealthly tracts, but it is believed to be so.' Hospital Assistant Jamiatram Jeyashunker, Nagar Brahmin, West Hospital, Rajkot, Kattiawar, says, 'Bhang is also tried with more or less success in many diseases, as in tetanus,... and in cholera.' Uttamram Jeewanram, Itchapooria, Audesh, Brahmin, Native Doctor (Vaidya), Bombay and Surat, says, 'Ganja and bhang are used in malarious tracts to prevent the malarious attacks. I have experienced that the consumers of bhang and ganja very rarely suffer from malarious fever.' Keshowram Haridat, Chcepooria, Audesh Brahmin, Native Doctor (Vaidya) , Render, Surat and Bombay, says, 'In malarious and unhealthy tracts use of ganja protects the man from malarious attacks.' Mr. Purbhuram Jeewanram, Nagar Brahmin, Native Doctor (Vaidya), Bombay, says, 'It prevents disease, and is known to prevent fever. Brahmins and banias use bhang as a food accessory. People in the mufussal use it to prevent attacks of fever.' Ramchandra Krishna Kothavale, Brahmin, Inamdur, Taluka Wai, in Satara District, says, 'It is used as a febrifuge in some malarial countries, but the use is not so well marked.' Rao Bahadur Govindrao Ramchandra Garud, Pleader Dhulia, Khandesh, says, 'Yes ; according to native works on medicine bhang has febrituge properties and is used in malarious and unhealthy tracts with such object.' Rao Bahadur Huchrao Achut Harihar, Deshast Brahmin, Pleader, District Court, Belgaum, says, 'as preventive of disease in malarious and unhealthy tracts;' Naro Dhakadeo, Brahmin, Pleader, Jalgaon, District Khandesh, says, 'as a preventive of disease in malarious and unhealthy tracts ; (d) to prevent diseases from dirty water.' Gurappa Rachappa, Lengayet, Office of Shetti (Revenue and Police), Dharwar, says, 'As febrifuge or preventive of disease to a certain extent in malarious and unhealthy tracts when mixed with cloves, dried ginger, jagri, and pipli.' Laldas Laxmonji, Kshatriya, Solicitor's Clerk, Bombay, says, 'It acts as a preventive of disease in unwholesome climates and where unwholesome water is only obtainable.' Mr. C. E. S. Stafford Steele, Officiating Deputy Commissioner, Thar and Parkar District, says, 'to induce perspiration in ague fits, when dry leaves are placed on embers and the smoke inhaled.' Khan Bahadur Kadirdad Khan Gul Khan, C.I.E., Deputy Collector, Naushahro Sub-division, says, 'the use of hemp liquid is considered as a preventive of disease in malarious and unhealthy tracts.' Muhammad Murid, Police Inspector, Naushahro, says, 'Bhang is prescribed by native doctors ...for stopping dysentery and diarrhœa.' Assistant Surgeon G. M. Dixon, Medical Officer and Superintendent, Nara Jail, says, 'acts as a febrifuge in malarious tracts....While this jail was in Thar and Parkar district in some malarious places, but very few of the surrounding free population came to be treated for fevers at this jail hospital, and among these men the moderate drinking of subzi was prevalent. In April and May last, when my camp was at Khadi, Barogoza Bund, a malarious and outof-the-way place in Shah Bunder subdivision of Karachi district, there were over a thousand free labourers working on the Bund, and among them there were but a few cases of fever, and no case of sunstroke, although they used to work in the sun under a temperature varying from 130º to 140ºF., the temperature in the shade being about 110ºF. Although I was not in direct medical charge of these free labourers, still, in order to pro tect the general health of my prisoners, I used to go about amongst the free labourers to find out if there was much sickness or epidemic among them, and good many of these free labourers used to take moderate quantity of subzi in the day time after finishing their work. Khadi is a small village containing about 60 fishermen, who have their temporary huts at the place during the fishing season. These people used to take subzi in moderate doses and all appeared to me to be heathy. Sunstroke and fever were almost unknown among them.' Pesumal Narumal, Farmer and Merchant, Hyderabad, says, 'Bhang is used as a febrifuge.' Waman Ganesh, Tahsildar, Wun, says, 'as a preventive of disease in malarious and unhealthy tracts;' Vimayak Appaji Kaur, Brahmin, Officiating Tahsildar, Darwa, Wun District, says, 'Moderate use of ganja or bhang is beneficial... is also effective as a medicine in malarious and unhealthy tracts.' Laxman Gopal Deshpande, Brahmin, Naib Tahsildar, Mangrul Taluk, District Basim, says, 'as a febrifuge or preventive of disease in malarious and unhealthy tracts.' Surgeon-Major C. L. Swaine, Officiating Sanitary Commissioner, and Inspector- General of Dispensaries, says, 'In the Melghat forest and malarial district ganja is much used as a preventative against malarial fevers;' Surgeon-Major R. B. Roe, Civil Surgeon, Amraoti, says, 'It (ganja) is also used as a febrifuge with good results.' Mr. Dinner Narayen, District Superintendent of Vaccination, Buldana, says, 'It is a preventive of diseases in malarious tracts.' G. V. Kot, Brahmin, Medical Practitioner, Amraoti, says, 'nearly 10 per cent, of the occasional moderate smokers use it as a febrifuge. I have been informed of cases in which attacks of intermittent fevers (ague) have disappeared by a single process of smoking ganja—cases I mean of jungle fevers, in which the administration of even large doses of quinine have failed to ward off the attacks or in districts in which quinine is not obtainable.' Yeshwant Vaman Dighe, Pleader, Basim, says, 'Ganja wards off the injurious effects of impure and unfiltered water (germicide).' Niamat Khan Bilan Khan, Merchant, Balapur, Akola District, says, 'I don't know about fever ; but I have heard from many sadhus that the use of bhang and ganja protects them against diseases in unhealthy tracts, by which I mean places where water is bad.' Lakshman Atmaram Mahajan, Merchant, Manjrul Pir, says, 'acts like a prevention of disease in malarious and unhealthy tracts.' Khab Bahadur Dr Sheikh Elahi Bux, Government Pensioner and Honorary Magistrate, Ajmere, says, 'Vaids, hakims and native doctors do prescribe the use of these drugs on account of their medicinal properties for dysentery, diarrhoea, cholera, ...tetanus...They serve as febrifuge or preventive of disease in malarious tracts.' Asghur Ali Khan, Hospital Assistant, Ajmere Dispensary, says, 'Moderate use of bhang is beneficial in its effects as ...preventing malarious diseases in unhealthy tracts.' Jati Amar Hansa, Baid, Ajmere, says, 'In cases of intermittent and other fevers, such as continued, quotidian, tertian, etc., it is very useful when given with cathartics.' Mr. A. Bopanna, Planter, Bepunaad, Green Hills, Coorg, says, 'I think it is preventive of disease in malarious and unhealthy tracts.' Lieutenant-Colonel C. B. Cooke, Commissioner of Pegu, says, 'Maung Lu Maung, Thugyi of Yindaw (Yamethin district), states :— Ganja is said to keep off cold and fever. It is still used medicinally by some suffering from long-standing dysentery and diarrhœa...Maung Gyi, Head Constable of Wundwin (Meiktila district), states: I was told that it was an antidote for fever...Maung Lat, Myook of Wundwin (Meiktila district), states :—Ganja I am told keeps away cold and fever. I have seen children suffering from dysentery cured by rubbing ganja pounded and mixed in water on the navel.' Surgeon-Major S. H. Dantra, Civil Surgeon, Mandalay, says, 'It has been also recommended as well as often used as a preventive against malaria and bowel complaints caused by change of climate or water or by marching through unhealthy districts.' Surgeon-Captain R. H. Castor, Civil Surgeon, Yemethin, says, 'Native doctors use it for diarrhœa and cholera'. Army Witness No. 83 says, 'The moderate use of these drugs is considered beneficial in the prevention of malaria and disease.' Army Witness No. 116 says, 'a regular consumer of bhang is said to be comparatively free from the diarrhœa and slight dysentery which non-consumers amongst natives are so liable to on the march or in a new station from drinking water with properties they are not accustomed to.' Army Witness No. 137 says, 'Indian hemp is of great value in cases of obstinate malarial fever, though not usually prescribed by English physicians.' Army Witness No. 162 says, 'If taken in moderation, the use of these drugs is supposed to be beneficial, inasmuch as it is said to promote digestion, create appetite and nullify the effects of bad water.' Army Witness No. 179 says, 'Ganja—Beneficial; taken in cases of men suffering from malarial fevers.'

Siva, the god of ganja, is also known as the god of fever.  According to the Note to the Indian Hemp Drugs Commission of 1894-95 by J. M. Campbell , C.I.E., Collector of Land Revenue and Customs and Opium, Bombay, on the Religion of Hemp, 'The Kashikhanda Purana tells how at Benares, a Brahman, sore-smitten with fever, dreamed that he had poured bhang over the self-sprung Ling and was well. On waking he went to the Ling, worshipped, poured bhang and recovered. The fame of this cure brings to Benares sufferers from fever which no ordinary medicine can cure. The sufferers are laid in the temple and pour bhang over the Ling whose virtue has gained it the name Jvareshwar, the Fever-Lord.'

Today, the world faces a situation where all the actions of the ruling upper classes of the world only further enhance the climate conducive for the thriving and proliferation of infectious diseases that are mutating to even more deadlier versions. The world faces a dead-end in terms of antibiotics, and a rapidly losing battle in the field of antivirals and antifungals. Increasing contamination of air, water, food and the soil threaten to unleash newer forms of deadly microbes, even as human and animal immunity levels drop. The stress caused by the actions of the world's elites is a major factor for the spread of infectious diseases worldwide. As if all this was not bad enough, rising global temperatures thaw and melt the icesheets that cover large areas of the Arctic and Antarctic, releasing prehistoric microbes that are frozen in the earth into a world that has forgotten how to deal with them.

We saw in the reports from 19th century India regarding the use of cannabis as prophylactic, febrifuge and antibiotic for the prevention and treatment of infectious diseases. The people who used cannabis as medicine against infectious diseases were the poorest sections of society, who formed the majority and who could afford nothing else as medicine. The global legalization of cannabis will enable the poorest people in the world, who form possibly 70% of the world's population, to use it as a means to combat infectious diseases. But this step is continuously blocked by the synthetic pharmaceutical, medical, chemical fertilizer and petrochemical industries that are today responsible for the heightened state of danger to all life. The products of these cannabis-opposing industries only benefit the top 10% of the world's people - the elites. But the power over decision-making that these elites hold prevents cannabis from reaching the people who need it the most. Opium may be an effective medicine in the treatment of infectious disease - primarily as a painkiller - but it is highly addictive and harmful. This is clearly evident from the increasing number of deaths from opioid overdoses worldwide. But this has not prevented the world's elites from positioning opium as the preferred medicine at the cost of cannabis. This is primarily because the global elites are addicted to opium and profit greatly from its use and sale. It does not matter to the elites that opium is difficult to procure for most of the people of the world, or that it is expensive and deadly. I believe that the Covid-19 fake pandemic was also created to boost the flagging opioid sales as global awareness increased regarding opium's harms, and global efforts to legalize cannabis as a replacement for opium increased. Today, to make matters worse, we see that the same culprits who were responsible for the fake pandemic Covid-19 are still in charge of world affairs - Xi, Narendra Modi, Vladmir Putin, the recently reinstated Donald Trump (only Boris Johnson has been decommissioned) - resolutely working to keep cannabis prohibited.

Recent scientific studies have started to show the potential of cannabis as an antibiotic. Cannabis legalization will have far-reaching benefits in the treatment and control of infectious diseases. Cannabis is universal medicine that addresses a wide range of health issues. Cannabis can be grown in almost all the countries of the world, unlike opium, thus enabling it to reach the poorest people in the remotest parts of the world. Cannabis legalization will have far-reaching benefits in the treatment and control of infectious diseases. It will even address the man-made sources of infectious diseases i.e. the contamination of the planet through wars, petrochemical-based products, synthetic pharmaceuticals, chemical pesticides, etc. It will enable humans and other living beings to boost their immunity levels through addressing stress, anxiety, nutrition, sleep, digestion, pain, etc. It will enable humans to raise their levels of thinking to creatively and inclusively address the problem of infectious diseases. It will enable humanity to be more alert to dangerous life-threatening endeavors like Covid-19 that the charlatans among the elites deploy to keep the world in chains and increase their own wealth and power - two most useless possessions that can be rendered meaningless by the smallest organisms that nature has created, organisms that exist all around us and within us, organisms that make a mockery of human intelligence and the delusions that come with it...

We live in a time when all life on earth, not just human, is at threat by the foolish actions of humans in their blind and relentless pursuit of wealth and power...We must deploy all possible defensive mechanisms against this threat, the likes of which the planet as we know it has never witnessed in living memory...Cannabis is one of the most potent defense mechanisms that nature has provided for the benefit of numerous life forms, not just humans...The longer we ignore cannabis and place our trust on the delusion that human intelligence - and the synthetic products that it creates - is far superior to nature, the closer we get to our collective demise...

Tuesday, 5 December 2023

Cannabis and Psychedelics

 

' The Hitchhiker's Guide to the Galaxy has this to say on the subject of flying.

There is an art, it says, or rather, a knack to flying.

The knack lies in learning how to throw yourself at the ground and miss.

Pick a nice day, it suggests, and try it.'

- The Hitchhiker's Guide to the Galaxy, The Complete Trilogy of Five, Douglas Adams

 
“[Entheogens are] defined as promoting life-altering experiences, profound insights, and spiritual connectedness, or ‘generating the God within,’” said Weiss. “Like psychedelics, the use of Cannabis sativa has been widely documented as a powerful shamanic medicine for thousands of years all over our planet—many people across the world view cannabis as a master plant or teacher.”'
 
 - Leafly 
 
 
'I was so high I had to lean my head back on the seat; the bouncing of the car sent shivers of ecstasy through me. The mere thought of looking out the window at Mexico - which was now something else in my mind - was like recoiling from some gloriously riddled glittering treasure-box that you're afraid to look at because of your eyes, they bend inward, the richness and the treasures are too much to take all at once. I gulped. I saw streams of gold pouring through the sky and right across the tattered roof of the poor old car, right across my eyeballs and indeed right inside them; it was everywhere. I looked out the window at the hot, sunny streets and saw a woman in a doorway and I thought she was listening to every word we said and nodding to herself - routine paranoic visions due to tea. But the stream of gold continued. For a long time I lost consciousness in my lower mind of what we were doing and only came around sometime later when I looked up from fire and silence like waking from sleep to the world, or waking from void to a dream'
 
 - On the Road, Jack Kerouac
 

'485. Judging from the replies of several witnesses, the immediate effect of the moderate use of any of the hemp drugs on the habitual consumer is refreshing and stimulating, and alleviates fatigue, giving rise to pleasurable sensations all over the nervous system, so that the consumer is "at peace with everybody"—in a grand waking dream. He is able to concentrate his thoughts on one subject: it affords him pleasure, vigour, ready wit, capacity for hard work, and sharpness for business; it has a quieting effect on the nervous system, and removes restlessness and induces forgetfulness of mental troubles; all sorts of grotesque ideas rapidly pass through the mind, with a tendency to talk; it brightens the eyes, and, like a good cigar, gives content; the man feels jolly, sings songs, and tells good stories; '

 - Indian Hemp Drugs Commission, 1895

Psychedelics, according to me, are a class of drugs that distort visual perceptions. They show reality in a way that the normal mind, with its filters in place, tends to push to the background to enable a person to perform the basic functions of day-to-day survival. Under the influence of psychedelics, the mind frees itself from its filters, and one gets to see everything in all its glory. Many of the common psychedelic experiences that have been documented talk about a compression of the evolution of the universe into a matter of a few minutes. This is the equivalent of a person in the last dying moments seeing all the life that has transpired flashing before the mind in a movie in fast forward. One gets to see the universe, emerging from the void, the creation of the earth, the beginning of life of earth, the transition of life from single cellular organisms to multicellular organisms, the emergence of humans, and on till the disappearance of the universe back into the void. Some psychedelics are said to give one an experience of the other world, the world of the dead and the spirits, that remain hidden behind the veil that our living minds have created. Other psychedelic experiences talk about the key bonds and relationships between the user and the people in the user's life, often seen through intimate details that reaffirm, heal or strengthen the bonds that existed. Many of these are to do with loved ones that have passed away, often through traumatic experiences. Some psychedelic experiences involve seeing nature in a way that one has never seen it before - radiant, blindingly colorful, mystical, wondrous, and magnificent. Almost all psychedelic experiences leave the user profoundly affected. Many are reduced to tears, and usually these tears are tears of joy.

It is for these reasons that psychedelics are now considered, by the urban man, potent healers of the human mind. It is said that just one psychedelic experience is sufficient to heal persons suffering from various kinds of psychological disorders. I attribute this ability of psychedelics to heal the mind to the process of re-mapping the mind's perception of reality. When one goes through various trauma in life, these experiences leave an indelible mark on the mind's map of reality. The picture that the mind tends to hold is one of a dark, grey, bleak, painful landscape of reality that brings with it pain and sorrow, pushing one gradually into a state of melancholy depression and a view of the world as dark, constricting, and suffocating. The use of a psychedelic erases this dark picture, and repaints the mind's map of reality in all its wondrous color and beauty. It is a reboot of the mind stuck in an endless loop of dreariness, so that the mind is vibrant, joyous and alive once again. The power of the psychedelic is such that once this map of reality is repainted, seldom does the individual revert back to the dark, gloomy states that once drove her to despair. The individual's mind retains a memory of this reboot, and goes back to it again and again, like an underwater mammal going to the surface for oxygen. That is why it is often stated that just one dose of a psychedelic is enough to permanently heal almost any kind of mental disorder. It is the act of being reborn, becoming the twice-born that many ritualistic, and sham processes practiced by religious orders created for the exploitation of the vulnerable claim to achieve.

Humans have been blessed to have discovered and been able to enjoy the use of psychedelics for thousands of years. I am of the firm belief that it is the use of psychedelics that set the human on a trajectory that separated the species from the apes and the chimpanzees. The evolution of the human mind to what it is now I largely attribute to the use of psychedelics.

There are numerous natural psychedelics that have been used for thousands of years. Some of the most well-known ones are psilocybin, peyote, ayahuasca, ibogaine. Psilocybin is a mushroom, peyote is a cactus, ayahuasca is a combination of two plants - stems of the Banisteriopsis caapi vine and the leaves of the Psychotria viridis shrub. Ibogaine is from the roots of Tabernanthe Iboga, a shrub indigenous to West Africa. Besides these, there are more dangerous natural psychedelics such as Jimson's weed or datura.

In terms of synthetic psychedelics, the compound lysergic acid diethylamide (LSD) probably takes the number one spot. Others claim seats at the table of psychedelics, newer substances like MDMA.

All psychedelics seem to have one key criterion for their effectiveness in producing the desired states of mind. That is the setting in which they are consumed. In all the cases, be it natural or synthetic psychedelics, it is of paramount importance that they are consumed in as natural a setting as possible. This is because all these psychedelics do one most important function as a part of their healing, and that is reconnect the human mind, lost in the labyrinth of human-made hell, back to nature. It is essentially a dose of nature that the human mind gets through the psychedelic that heals it. Maybe, with the synthetic psychedelics created in the laboratories of man, this natural setting is not of paramount important. But with the natural psychedelics, I would say that it is the number one criterion required to feel its full effect. That is why most experienced users of psychedelics, primarily the indigenous communities that practiced its use for thousands of years, used it for healing in their natural surroundings. The problems arose when modern urban man, with his mind disconnected from nature and living in man-made hell, went out and brought back these psychedelics to his urban hell. There are numerous instances where the use of the natural psychedelic in an inappropriate urban setting, in order to amplify the pleasures of the synthetic setting that man had placed himself in, resulted in hellish experiences as the mind sought to make a connection with its synthetic surroundings, only to create nightmarish experiences for the user. This led to the conclusion by the misdirected man that the psychedelic was harmful and dangerous. The foolish urban human then decided to prohibit all psychedelics, natural and synthetic, taking it out of the hands of the indigenous communities that viewed the natural psychedelics as sacred pathways for their communion with the eternal spirit that they were themselves a part of. All natural psychedelics are considered to be entheogens by the indigenous communities that use them.

Psilocybin, MDMA and LSD are said to be serotonergic hallucinogens with their primary mechanism of action is on serotonin receptors in the brain. Cocaine and amphetamine act on the dopamine receptors. Opioids act on the mu and sigma receptors. Alcohol acts on the GABA A and NMDA glutamate receptors. Cannabis acts on the CBR1 and CBR2 receptors. Although various drugs act on various receptors, the ultimate result is a re-writing of brain maps in such a way that the internal visual machinery of the brain creates images in the mind, bypassing or altering the normal visual processes that involve the external facing eye and retina. One of the key differences between safe natural psychedelics like - psilocybin, peyote and cannabis - and the synthetic psychedelics - such as cocaine, methamphetamine, and opioids - is that these natural psychedelics do not damage the brain machinery, unlike the synthetic ones. I believe the above listed natural psychedelics actually aid in healing damaged brain machinery, which is why they are not addictive. It is also the reason why these natural psychedelics are used to heal brains damaged from cocaine, methamphetamine and opioid addictions, and to wean users away from the synthetic psychedelics that build dependence. Dependence here means that once a person is used to these synthetic psychedelics, that user is unable to function normally without these synthetics, whereas with the natural psychedelics no such dependency is built, since the brain machinery remain intact, or possibly even better, post usage. Of course, there are dangerous natural psychedelics that severely damage brain cells. Dhatura, belonging to the same natural order as hyoscyamus and belladonna, has the active principle hyoscyamine with small quantities of atropine and hyoscine. The active principle of belladonna is atropine with some hyoscyamine. These are some examples of freely available dangerous natural psychedelics. Studies done by Dr. D D Cunningham on a rhesus macaque, in the 1890s, with dhatura showed extensive damage of brain tissue within a short period of time. Some of the bad propaganda associated with cannabis is due to the usage of substances like dhatura, opium, arsenic, and nux vomica (containing the toxin scopalamine) as admixtures with cannabis, with cannabis finally getting the bad rap.

Most natural psychedelics are found only in specific geographies. Hence they are difficult to obtain by the world at large. For example, peyote is typically found only in South and Central America, psilocybin is found in parts of America and a few other places in the world. Ibogaine as stated earlier is typically found in West Africa. The synthetic psychedelics can, of course, be created in a lab anywhere, provided that one has the necessary ingredients.

Nearly all psychedelics are ingested and their effects kick in once the digestive system starts breaking them down. This usually takes a few minutes to a couple of hours. Natural psychedelics typically are emetic, i.e. they produce nausea and vomiting.

It is quite common in the use of psychedelics for the novice user to have an experienced guide to accompany one on the journey. The guide is typically an experienced psychedelic user who ensures that the novice does not have a bad experience. This is done by talking the novice user through the early stages of the experience, and calming down the anxieties and apprehensions that the novice user may have. The guide also ensures that adverse experiences are kept to a minimum, and that the novice user is able to emerge from the experience without any difficulties. You could call this the equivalent of a novice pilot being accompanied by an experienced flier on his or her first flight.

One of the key questions that is often asked is whether cannabis is a psychedelic. My take on this is an emphatic yes, cannabis is a psychedelic. I have personally experienced profound alterations of reality with good cannabis. Some examples of such experiences that I have had are - having a mental image of the world as yin and yang - with life emerging from one side of the world and life disappearing into another side of the world; faces of persons that I am in conversation with distorting to emerge as radiant, angelic and beautiful beyond words; erotic imagery emerging from dark shadows where there may have been none in conventional reality. I found a description of the face distortion aspects of cannabis in Jack Kerouac's book On the Road. In this, he writes about his marijuana experience in Mexico as follows - ''For a mad moment I thought Dean was understanding everything he said by sheer wild insight and sudden revelatory genius inspired by his glowing happiness. In that moment, too, he looked so exactly like Franklin Delano Roosevelt - some delusion in my flaming eyes and floating brain - that I drew up in my seat and gasped with amazement. In myriad pricklings of heavenly radiation I had to struggle to see Dean's figure, and he looked like God.' 

The effects of seeing the world in beautiful, colorful, radiant detail is one that I have quite frequently, in fact, every time I have smoked cannabis. This effect of cannabis is comparable to what others have described as effects from consuming psilocybin or mescaline, which I have not yet had the good fortune to enjoy, and also LSD. Kerouac also speaks about this visual beauty in On the Road. He says - 'I was so high I had to lean my head back on the seat; the bouncing of the car sent shivers of ecstasy through me. The mere thought of looking out the window at Mexico - which was now something else in my mind - was like recoiling from some gloriously riddled glittering treasure-box that you're afraid to look at because of your eyes, they bend inward, the richness and the treasures are too much to take all at once. I gulped. I saw streams of gold pouring through the sky and right across the tattered roof of the poor old car, right across my eyeballs and indeed right inside them; it was everywhere. I looked out the window at the hot, sunny streets and saw a woman in a doorway and I thought she was listening to every word we said and nodding to herself - routine paranoic visions due to tea. But the stream of gold continued. For a long time I lost consciousness in my lower mind of what we were doing and only came around sometime later when I looked up from fire and silence like waking from sleep to the world, or waking from void to a dream, and they told me we were parked outside Victor's house and he was already at the door of the car with his little baby son in his arms, showing him to us.' Another distortion, or rather I should say clarity that I have experienced with cannabis, has to do with listening to music under its influence. There have been occasions when I have felt myself immersed in a pool of sound created by the music floating out of the speakers, hearing sounds and details that I never heard before, despite having listening to the same musical piece numerous times.

Many persons are averse to considering cannabis as a psychedelic. This may be because of the poor quality of cannabis that they have consumed, or a problem with their mental make up and its lack of receptivity and plasticity. It also may be because of the myths and stereotypes that have been created around cannabis in the last 150 years or so, that cannabis is a harmful drug, that it is a recreational drug, that it is used by despicable lower classes and castes, and other races and ethnic groups who are ignorant and stupid.

The distortion of time and space is an effect of cannabis that many persons have experienced and spoken of. Time seems to stand still. Space loses its rigid dimensions and starts to appear fluid and flowing. The senses become heightened to a great extent. One is able to hear the faintest and most distant sounds. One is able to feel the lightest of touches. One's sense of taste and smell get heightened to a great extent, and this is almost always in a pleasant way. Some of these effects are responsible for cannabis being considered an aphrodisiac par excellence.

The Indian Hemp Drugs Commission of 1895 says the following regarding the immediate effects of cannabis usage - 'Dr. Russell (Bengal witness No. 105), in his note furnished to Dr. Prain, gives the following effects of "doses pushed to produce a decided effect": "Mental effects appear in from three to five minutes; exhilaration and excitement of a pleasing nature: the subject talkative and merry; laughs and gesticulates; plays on imaginary musical instruments and sings; converses with imaginary persons; illusions and delusions, usually of a pleasing nature;' In its summary on the immediate effects of cannabis consumption, the Commission states that - '485. Judging from the replies of several witnesses, the immediate effect of the moderate use of any of the hemp drugs on the habitual consumer is refreshing and stimulating, and alleviates fatigue, giving rise to pleasurable sensations all over the nervous system, so that the consumer is "at peace with everybody"—in a grand waking dream. He is able to concentrate his thoughts on one subject: it affords him pleasure, vigour, ready wit, capacity for hard work, and sharpness for business; it has a quieting effect on the nervous system, and removes restlessness and induces forgetfulness of mental troubles; all sorts of grotesque ideas rapidly pass through the mind, with a tendency to talk; it brightens the eyes, and, like a good cigar, gives content; the man feels jolly, sings songs, and tells good stories;' 

It is many of the psychedelic effects of cannabis that makes it the world's most widely used entheogen. The feeling of being at peace with everything, the feeling of connectedness with everything, the feeling that all is the spirit, the feeling that everything is in god, and that everything is god, are all reasons why cannabis is the most widely used spiritual aid.

Psychedelic research is one of the areas of mind research that is seeing a resurgence in the west these days, after being stamped out by the paranoia created by government agencies, especially in the US after the 1960s. Organizations such as the Multidisciplinary Association for Psychedelic Studies (MAPS) are among the forerunners in psychedelic research in the US today. There are growing movements to bring about the legalization of natural psychedelics, mainly peyote and psilocybin, especially in US states, such as Colorado, that have legalized adult recreational cannabis use for over a decade now. Some indigenous communities have been permitted to use natural psychedelics as a part of their spiritual practices by law courts in the US.

I have not had a chance to consume any of the other natural psychedelics, besides cannabis. Peyote and ayahuasca are not native to where I grew up and now reside. Psilocybin mushrooms can be found in South India, but I have not yet had the opportunity to consume them. If I ever did, I would prefer to do so in the natural settings where they grow. I am averse to trying out LSD, and this aversion exists for all synthetic human-made drugs, be they recreational or pharmaceutical.

While it is necessary to legalize all natural psychedelics, and to take them out of the list of banned substances in global drug laws, it is of paramount importance to legalize cannabis first and foremost. Cannabis is the one natural psychedelic with the safest profile that grows all over the world, making it accessible to every geographical demographic, and to the most number of humans. It can be consumed in multiple ways. It can be dosed in various quantities without producing dangerous effects. It does not need the presence of a guide as much as the other psychedelics, though novice users may benefit from their presence. It can be consumed by various age groups and all genders, though for young children it is typically given as medicine. The other natural psychedelics can only benefit users who are in close proximity to them, or those who can afford to access them. 

The mind healing psychedelic aspect of cannabis is urgently required for a collective humanity that has lost its connection with nature, a humanity that now, because of this distortion of reality, attempts to recreate the same bleak landscape that it finds inside its mind in the natural world outside. If we do not do this quickly enough it would be world wide suicide...with us taking down numerous other living beings along with us due to our own collective insanity...

Related articles

The following articles speak about psychedelics, and also cannabis as a psychedelic.


Psychedelics are known to disrupt another major cluster of brain regions: the default-mode network (DMN). The DMN is associated with self-referential thought, like daydreaming about the moment you win the Olympics, or recalling autobiographical memories, like winning the Olympics if you’d actually won the Olympics. It’s the brain’s hub for the narrative self.

Psychedelics reduce activity within the DMN, while increasing activity between the DMN and other brain regions. Christopher Timmermann, a neuroscientist who leads the DMT Research Group at Imperial College London (DMT is a psychedelic drug, like LSD or psilocybin), explained to me earlier this year that “parts of the DMN become hyper-connected with the rest of the brain.”

During interviews after their DMT trips, he said that participants report things like “I was observing the experience, but at the same time I was everything. I was every possible concept in my mind.” Trippy, yes, but it “resonates with this idea of hyperconnectivity,” he said. “These resources we have when it comes to the sense of self become more promiscuous, and become attached to larger systems of meaning.”

https://www.vox.com/future-perfect/23972716/psychedelics-meaning-science-psychedelic-mushrooms-ketamine-psilocybin-mysticism


'Beyond laughs, Chappelle’s openness about substance use has also made a serious impact on the drug policy reform debate. Former NAACP head and Maryland gubernatorial candidate Ben Jealous, for example, said it was Chappelle who first convinced him that marijuana should be legal.

In her interview this week with Rock, DeGeneres said she’d be wary of tripping. “I think I would be freaked out,” she said. “Everyone that goes there drinks the mushroom tea?”

“Yeah, man!” Rock said. “We’re in a cornfield in a pandemic. What have you got to lose?”'

https://www.marijuanamoment.net/dave-chappelles-marijuana-and-psychedelics-parties-dont-concern-local-sheriff/


'Studies seem to show that some psychedelic drugs can relieve the symptoms of chronic mental illnesses, including addiction, PTSD and severe depression, possibly by helping the brain to create new connections between neurons. Ongoing clinical trials are attempting to use the magic-mushroom compound psilocybin, LSD (lysergic acid diethylamide) and MDMA (3,4-methylenedioxymethamphetamine, also known as ecstasy) to treat various psychiatric disorders.

But these drugs’ hallucinogenic properties make them difficult to administer, because the recipients require constant supervision, and the hallucinatory effects can be a challenging experience. Some researchers are now looking for psychedelic-like molecules that retain the therapeutic potential without the trippy side effects.'

https://www.nature.com/articles/d41586-021-01156-y


'Magic mushrooms, or shrooms, and LSD, or acid, are two of the most common psychedelics and they have a lot of similarities. Both are recognized as classic psychedelics, with a meaningful influence on science and culture, and both have been identified as physiologically safe with a low risk of sparking dependency in consumers. What’s more, mushrooms and LSD are serotonergic hallucinogens, so their primary mechanism of action is on serotonin receptors in the brain.

But do these similarities mean shrooms and acid are more or less interchangeable? How do shrooms stack up against acid when it comes to effects, ingestion method, dosage, onset time, and trip duration? What distinguishes an acid trip from a mushroom trip, if anything at all?'

https://www.leafly.com/learn/psychedelics/types-of-psychedelics/shrooms-vs-acid


'How do the doses and descriptions above compare to what has been observed in controlled, human clinical trials? In some of the pioneering psilocybin studies done at Johns Hopkins University, controlled doses of psilocybin were administered to patients.

The studies gave people a range of psilocybin doses and generally found that high doses often induced a “mystical-type experience,” the formal research definition for what we might call a “full-blown psychedelic experience.”

The doses given to induce such effects were in the 20-30 milligram range for psilocybin, or between the medium and high doses in the dosing guide above.

In other words, a full eighth-ounce, or 3.5 grams, of dried P. cubensis is likely to contain more psilocybin than the doses given to reliably induce mystical-type experiences in controlled human studies.'

https://www.leafly.com/learn/psychedelics/how-to-dose-mushrooms


'The director said researchers have “had all kinds of limitations” and there’s “limited opportunity for access.” He noted that the Drug Enforcement Administration (DEA) has recently moved to expand the number of marijuana manufacturers, but he said what the government “really needs” to do is “moderate the Schedule I limitation.”

He said he’s spoken with NIDA Director Nora Volkow about the issue and feels there should be a modified Schedule I category called Schedule I-R, “which would be basically a different pathway if you’re going to use this material for research.”'

https://www.marijuanamoment.net/top-federal-health-official-touts-psychedelics-therapeutic-benefits-and-slams-marijuana-scheduling/


'Weiss points out that rather than debating whether or not cannabis could be understood as a psychedelic, it could be more useful to identify both as entheogens.

“[Entheogens are] defined as promoting life-altering experiences, profound insights, and spiritual connectedness, or ‘generating the God within,’” said Weiss. “Like psychedelics, the use of Cannabis sativa has been widely documented as a powerful shamanic medicine for thousands of years all over our planet—many people across the world view cannabis as a master plant or teacher.”'

https://www.leafly.com/learn/psychedelics/is-weed-a-psychedelic


'The Drug Enforcement Administration (DEA) is proposing a massive increase in the production of marijuana and psilocybin for research purposes, with the intent of aiding in the development of new federally approved therapeutic medications.

In a notice set to be published in the Federal Register on Thursday, DEA said it is proposing “significant increases” in the manufacturing of “the schedule I substances psilocybin, psilocin, marihuana, and marihuana extract, which are directly related to increased interest by DEA registrants in the use of hallucinogenic controlled substances for research and clinical trial purposes.”

“DEA firmly believes in supporting regulated research of schedule I controlled substances,” it said. “Therefore, the [Aggregate Production Quota] increases reflect the need to fulfill research and development requirements in the production of new drug products, and the study of marijuana effects in particular, as necessary steps toward potential Food and Drug Administration (FDA) approval of new drug products.”'


'The Biden administration proposed a change to the federal drug scheduling system on Thursday that it hopes will streamline research into Schedule I controlled substances including marijuana and psychedelics such as psilocybin.

The White House Office of National Drug Control Policy (ONDCP) said in a letter to congressional leaders and a plan posted on the agency’s website that it wants to encourage research in part by simplifying the registration process for scientists to access Schedule I drugs so that they match those for less-restricted Schedule II substances.

This is part of a broader White House initiative to develop what it says is a strategy to reduce the supply of illicit fentanyl analogues, while “protecting civil rights, and reducing barriers to scientific research for all schedule I substances.”'

https://www.marijuanamoment.net/bidens-drug-czar-wants-to-make-it-easier-to-research-marijuana-psychedelics-and-other-schedule-i-substances/


' The Hitchhiker's Guide to the Galaxy has this to say on the subject of flying.

There is an art, it says, or rather, a knack to flying.

The knack lies in learning how to throw yourself at the ground and miss.
Pick a nice day, it suggests, and try it.
The first part is easy.
All it requires is simply the ability to throw yourself forward with all you weight, and the willingness not to mind that it's going to hurt.
That is, it's going to hurt if you fail to miss the ground.
Most people fail to miss the ground, and if they are really trying properly, the likelihood is that they will fail to miss it fairly hard.
Clearly, it is this second part, the missing, which presents the difficulties.
One problem is that you have to miss the ground accidentally. It's no good deliberately intending to miss the ground because you won't. You have to have your attention suddenly distracted by something else when you're halfway there, so that you are no longer thinking about falling, or about the ground, or about how much it's going to hurt if you fail to miss it.
It is notoriously difficult to prise your attention away from these three things during the split second you have at your disposal. Hence most people's failure, and their eventual disillusionment with this exhilarating and spectacular sport.
If, however, you are lucky enough to have your attention momentarily distracted at the crucial moment by, say, a gorgeous pair of legs (tentacles, pseudopodia, according to phylum and/or personal inclination), or a bomb going off in your vicinity, or by suddenly spotting an extremely rare species of beetle crawling along a nearby twig, then in your astonishment you will miss the ground completely and remain bobbing just a few inches above it in what might seem to be a slightly foolish manner.'

- The Hitchhiker's Guide to the Galaxy, The Complete Trilogy of Five, Douglas Adams


'Nowadays, peyote is mostly used by indigenous Americans, members of the Native American Church, or individuals such as Stebbins looking to experience a transformative psychedelic trip.

Peyote is currently recognized as an endangered or threatened plant and with its Schedule I drug classification, there have been few clinical studies of mescaline since the 1970s. While the psychedelic research renaissance is underway with studies on psilocybin, LSD, MDMA, ketamine, and DMT exploding, mescaline has been somewhat sidelined.

That being said, there’s significant evidence to suggest mescaline holds therapeutic potential in treating mental health disorders such as depression, anxiety, migraines, obsessive-compulsive disorder, and addiction.

In a 2021 survey of mescaline consumers, researchers reported that 68-86% of individuals with depression, anxiety, PTSD, and addictive disorders experienced an improvement following their most memorable mescaline experience. Among these participants, 35-50% rated their mescaline experience as one of the five most spiritually meaningful experiences of their lives. '

https://www.leafly.com/learn/psychedelics/types-of-psychedelics/peyote-mescaline


'The Drug Enforcement Administration (DEA) is proposing a dramatic increase in the legal production of marijuana and psychedelics like psilocybin, LSD, MDMA and DMT to be used in research next year.

In a notice scheduled to be published in the Federal Register on Monday, the agency said there’s been a “significant increase in the use of schedule I hallucinogenic controlled substances for research and clinical trial purposes,” and it wants authorized manufacturers to meet that growing demand.'

https://www.marijuanamoment.net/dea-proposes-dramatic-increase-in-marijuana-and-psychedelic-production-in-2022-calling-for-6300-percent-more-mdma-alone/


'“We have a contract with DEA. We are growing cannabis for [Food and Drug Administration] clinical trials and selling it to the DEA,” she said. “It’s unconscionable the way they are behaving—and further proof that the word ‘cannabis’ continues to be completely radioactive even though this is a 100 percent federally legal operation.”

“Fortunately, there are banks that care about the progress of federally regulated and federally legal research and are eager to step up and support us immediately,” Sisley added. “We will be moving our funding from Bank of America and never returning there. Our research continues without harm because other banks that care about scientific freedom were able to step up. Bank of America doesn’t even have the decency to provide an explanation after a decade of banking with an openly plant-touching business.”'

https://www.marijuanamoment.net/bank-of-america-cancels-account-of-marijuana-and-psychedelics-research-institute-registered-with-dea/


'But now the bouncing was no longer unpleasant; it was the most pleasant and graceful billowy trip in the world, as over a blue sea, and Dean's face was suffused with an unnatural glow that was like gold as he told us to understand the springs of the car now for the first time and dig the ride. Up and down we bounced, and even Victor understood and laughed.' - On the Road, Jack Kerouac


'For a mad moment I thought Dean was understanding everything he said by sheer wild insight and sudden revelatory genius inspired by his glowing happiness. In that moment, too, he looked so exactly like Franklin Delano Roosevelt - some delusion in my flaming eyes and floating brain - that I drew up in my seat and gasped with amazement. In myriad pricklings of heavenly radiation I had to struggle to see Dean's figure, and he looked like God. I was so high I had to lean my head back on the seat; the bouncing of the car sent shivers of ecstasy through me. The mere thought of looking out the window at Mexico - which was now something else in my mind - was like recoiling from some gloriously riddled glittering treasure-box that you're afraid to look at because of your eyes, they bend inward, the richness and the treasures are too much to take all at once. I gulped. I saw streams of gold pouring through the sky and right across the tattered roof of the poor old car, right across my eyeballs and indeed right inside them; it was everywhere. I looked out the window at the hot, sunny streets and saw a woman in a doorway and I thought she was listening to every word we said and nodding to herself - routine paranoic visions due to tea. But the stream of gold continued. For a long time I lost consciousness in my lower mind of what we were doing and only came around sometime later when I looked up from fire and silence like waking from sleep to the world, or waking from void to a dream, and they told me we were parked outside Victor's house and he was already at the door of the car with his little baby son in his arms, showing him to us.'

 - On the Road, Jack Kerouac


Osmond’s close friend, the writer Aldous Huxley, promoted French philosopher Henri Bergson’s theory of the brain as a filter which reduced information, like sensory inputs or memories, so reality wasn’t so overwhelming. Bergson wrote that without that filter, people might be able to remember everything that had ever happened to them, or perceive everything occurring in the universe—accessing a kind of clairvoyance.

Huxley thought this was how psychedelics could lead to telepathy. He wrote that psychedelics might turn off the “reducing valve” in the brain, and people could be telepathic and have access to other mystical experiences. This theory is directly related to the title of his book, The Doors of Perception, which comes from a William Blake quote, “If the doors of perception were cleansed, everything would appear to man as it is, infinite.”

https://www.vice.com/en/article/z34xa5/the-long-strange-relationship-between-psychedelics-and-telepathy


'"If you don't know, come to learn...if you know, come to teach." - motto on invitations to National DAs convention in Vegas, April 25-29, 1971

The first session - the opening remarks - lasted most of the afternoon. We sat patiently through the first two hours, although it was clear from the start that we weren't going to learn anything, and it was equally clear that we'd be crazy to try any teaching. It was easy enough to sit there with a head full of mescaline and listen to hour after hour of irrelevant gibberish...There was certainly no risk involved. These poor bastards didn't know mescaline from macaroni.

I suspect we could have done the whole thing on acid...except for some of the people; there were faces and bodies in that group who would have been absolutely unendurable on acid. The sight of a 344-pound police chief from Waco, Texas, necking openly with his 290-pound wife (or whatever woman he had with him) when the lights were turned off for a Dope Film was just barely tolerable on mescaline - which is mainly a sensual/surface drug that exaggerates reality, instead of altering it - but with a head full of acid, the sight of two fantastically obese human beings far gone in a public grope while a thousand cops all around them watched a movie about the "dangers of marijuana" would not be emotionally acceptable. The brain would reject it: the medulla would attempt to close itself off from the signals it was getting from the frontal lobes...and the middle-brain, meanwhile, would be trying desperately to put a different interpretation on the scene, before passing it back to the medulla and the risk of physical action.'

- Fear & Loathing in Las Vegas: A Savage Journey to the Heart of the American Dream, Part II...by Raoul Duke, November 25, 1971, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson


'Acid is a relatively complex drug, in its effects, while mescaline is pretty simple and straightforward - but in a scene like this, the difference was academic. There was simply no call, at this conference, for anything but a massive consumption of Downers: reds, grass, and booze, because the whole program had apparently been set up by people who had been in a Seconal stupor since 1964.

Here were more than a thousand top-level cops telling each other "we must come to terms with the drug culture," but they had no idea where to start. They couldn't even find the goddamn thing. There were rumours in the hallways that maybe the Mafia was behind it. Or perhaps the Beatles. At one point somebody in the audience asked Bloomquist if he thought Margaret Mead's "strange behavior," of late, might possibly be explained by a private marijuana addiction.

"I really don't know," Bloomquist replied. "But at her age, if she did smoke grass, she'd have one hell of a trip."

The audience roared with laughter at this remark.'

- Fear & Loathing in Las Vegas: A Savage Journey to the Heart of the American Dream, Part II...by Raoul Duke, November 25, 1971, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson


'The girl riding with me tonight is looking for an old boyfriend who moved out of Boston and is now living, she says, in a chicken coop in a sort of informal commune near Greenville, N.H. It is five or six degrees above zero outside and she doesn't even have a blanket, much less a sleeping bag, but this doesn't worry her. "I guess it sounds crazy," she explains. "we don't even sleep together. He's just a friend. But I'm happy when I'm with him because he makes me like myself."

Jesus, I thought. We've raised a generation of stone desperate cripples. She is twenty-two, a journalism grad from Boston University, and now - six months out of college - she talks so lonely and confused that she is eagerly looking forward to spending a few nights in a frozen chicken coop with some poor bastard who doesn't even know she's coming.

The importance of Liking Yourself is a notion that fell heavily out of favor during the coptic, anti-ego frenzy of the Acid Era - but nobody guessed, back then, that the experiment might churn up this kind of hangover, a whole subculture of frightened illiterates with no faith in anything.'

- The Campaign Trail: Fear and Loathing in New Hampshire, March 2, 1972, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson


'"Wonderful," I said. "That's one more summer that I have an excuse to avoid. But what happened? Why do they blame me?"

"Jesus Christ!" he said. "That crazy sonofabitch got on the train wearing your press badge and went completely crazy. He drank about ten martinis before the train even got moving, then he started abusing people. He cornered some poor bastard from one of the Washington papers and called him a Greasy Faggot and a Community Buttfucker...then he started pushing him around and saying that he was going to throw him off the train at the next bridge...we couldn't believe it was happening. He scared one of the network TV guys so badly that he locked himself in one of the lavatories for the rest of the trip."

"Jesus, I hate to hear this," I said. "But nobody really thought it was me, did they?"

"Hell, yes, they did," he replied. "The only people on the train who even know what you look like were me and - and -," (He mentioned several reporters whose names needn't be listed here.) "But everybody else just looked at that ID badge he was wearing, and pretty soon the word was all the way back to Muskie's car that some thug named Thompson from a thing called Rolling Stone was tearing the train apart. They were going to send Rosie Grier up to deal with you, but Dick Stewart [Muskie's press secretary] said it wouldn't look good to have a three-hundred-pound bodyguard beating up journalists on the campaign train."

"That's typical Muskie-staff thinking," I said. "They've done everything else wrong, why balk at stomping a reporter?"

He laughed. "Actually," he said, "the rumor was that you'd eaten a lot of LSD and gone wild - that you couldn't help yourself."

- The Campaign Trail: The Banshee Screams in Florida, April 13, 1972, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson


'Chitty and I met him the night before, about two thirty, in the lobby of the Ramada Inn where the press party was quartered. We were heading out to the street to look for a sandwich shop, feeling a trifle bent & very hungry...and as we passed the front desk, here was this huge wild-eyed monster, bellowing at the desk clerk about "All this chickenshit" and "All these pansies around here trying to suck up to Muskie" and "Where the fuck can a man go in this town to have a good time, anyway?"

A scene like that wouldn't normally interest me, but there was something very special about this one - something abnormally crazy in the way he was talking. There was something very familiar about it. I listened for a moment and recognized the Neal Cassady speed-booze-acid rap - a wild combination of menace, madness, genius, and fragmented coherence that wrecks havoc on the mind of any listener.

This is not the kind of thing you expect to hear in the lobby of the Ramada Inn, and especially not in West Palm Beach - so I knew we had no choice but to take this man along with us.

"Don't mind if I do," he said. "At this hour of the night I'll fuck around with just about anybody."

He'd just got out of jail, he explained, as we walked five or six blocks through the warm midnight streets to a twenty-four-hour hamburger place, called the Copper Penny. Fifteen days for vagrancy, and when he hit the bricks today around four he just happened to pick up a newspaper and see that Ed Muskie was in town...'

- The Campaign Trail: The Banshee Screams in Florida, April 13, 1972, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson


'He said a few things that I never really absorbed, but there was nothing he could have said, at that moment, as eloquent or as meaningful as that incredible smile on his face.

'The most common known source of ibogaine is from the roots of Tabernanthe Iboga, a shrub indigenous to West Africa. As early as 1869, TI roots were reported effective in combating sleep or fatigue and in maintaining alertness when ingested by African natives.

Extracts of TI are used by natives while stalking game; it enables them to remain motionless for as long as two days while retaining mental alertness. It has been used for centuries by natives of Africa, Asia, and South America in conjunction with fetishistic and mythical ceremonies. In 1905 the gross effects of chewing large quantities of TI were described..."Soon the nerves get tense in an extraordinary way; an epileptic-like madness comes over him, during which he becomes unconscious and pronounces words which are interpreted by the older members of the group as having a prophetic meaning and to prove that the fetish has entered him."

At the turn of the century, iboga extracts were used as stimulants, aphrodisiacs, and inebriants. They have been available in European drug stores for over 30 years. Much of the research with ibogaine has been done with animals. In the cat, for example, 2-10 mg/kg. given intravenously caused marked excitation, dilated pupils, salivation, and tremors leading to a picture of rage. There was an alerting reaction, obvious apprehension and fear, and attempts to escape...In human studies, at a dose of 300 mg. given orally, the subject experiences visions, changes in perception of the environment, and delusions or alterations of thinking. Visual images become more vivid, with animals often appearing. Ibogaine produces a state of drowsiness in which the subject does not wish to move, open his eyes, or be aware of his environment. Since there appears to be an inverse relationship between the presence of physical symptoms and the richness of the psychological experience, the choice of environment is an important consideration. Many are disturbed by lights or noises...Dr. Claudio Naranjo, a psychotherapist, is responsible for most current knowledge regarding ibogaine effects in humans. He states: "I have been more impressed by the enduring effects resulting from ibogaine than by those from sessions conducted with any other drug."'

- from a study by PharmChem Laboratories, Palo Alto, California.'

- The Campaign Trail: More Late News from Bleak House, May 11, 1972, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson


'Not much has been said about the Ibogaine Effect as a serious factor in the presidential campaign, but toward the end of the Wisconsin primary race - about a week before the vote - word leaked out that some of Muskie's top advisers had called in a Brazilian doctor who was said to be treating the candidate with "some kind of strange drug" that nobody in the press corps had ever heard of.

It had been common knowledge for many weeks that Humphrey was using an exotic brand of speed known as "Wallot"...and it had long been whispered that Muskie was into something heavy, but it was hard to take the talk seriously until I heard about the appearance of the mysterious Brazilian doctor. That was the key.

I immediately recognized the Ibogaine Effect - from Muskie's tearful breakdown on the flatbed truck in New Hampshire, the delusional and altered thinking that characterized his campaign in Florida, and finally the condition of "total rage" that gripped him in Wisconsin.

There was no doubt about it: the Man from Maine had turned to massive doses of ibogaine as a last resort. The only remaining question was "when did he start?" But nobody could answer this one, and I was not able to press the candidate himself for the answer because I was permanently barred from the Muskie campaign after that incident on the Sunshine Special in Florida...and that scene makes far more sense now than it did at that time.'

- The Campaign Trail: More Late News from Bleak House, May 11, 1972, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson


'McGOVERN AND FRIEND

"Sen. George McGovern (D-SD), shown here campaigning in Nebraska where he has spent 23 hours a day for the past six days denying charges by local Humphrey operatives that he favors the legalization of Marijuana, pauses between denials to shake hands for photographers with his "old friend" Hunter S. Thompson, the notorious National Correspondent for Rolling Stone who was recently identified by Newsweek magazine as a vicious drunkard and known abuser of hard drugs."

A thing like that would have finished him here in Nebraska. No more of that "Hi, sheriff" bullshit; I am now the resident puff adder...and the problem is very real. In Ohio, which McGovern eventually lost by a slim nineteen-thousand-vote margin, his handlers figure perhaps ten thousand of those were directly attributable to his public association with Warren Beatty, who once told a reporter somewhere that he favored legalizing grass. This was picked up by the worthless asshole Sen. Henry Jackson (D.Wash.) and turned into a major issue.

So it fairly boggles the mind to think what Humphrey's people might do with a photo of McGovern shaking hands with a person who once ran for Sheriff of Aspen on the Freak Power ticket, with a platform embracing the use and frequent enjoyment of Mescaline by the sheriff and all his deputies at any hour of the day or night that seemed Right.'

- The Campaign Trail: Crank-Time on the Low Road, June 8, 1972, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson


'"Don't worry," I assured them. "You'll be proud of me. There's a lot of bad blood between me and John Chancellor. He put acid in my drink last month at the Democratic Convention, then he tried to humiliate me in public."

"Acid? Golly, that's terrible! What kind of acid?"

"It felt like Sunshine," I said.

"Sunshine?"

"Yeah. He denied it, of course - But hell, he always denies it."

"Why?" a girl asked.

"Would you admit to a thing like that?" I said.

She shook her head emphatically. "But I wouldn't do it, either," she said. "You could kill somebody my making them drink acid - why would he want to kill you?"

I shrugged. "Who knows? He eats a lot of it himself." I paused, sensing confusion..."Actually, I doubt if he really wanted to kill me. It was a hell of a dose, but not that strong." I smiled. "All I could remember is that first rush: it came up my spine like nine tarantulas...drilled me right to the bar stool for two hours; I couldn't speak, couldn't even blink my eyes."

"Boy, what kind of acid does that?" somebody asked.

"Sunshine," I said. "Every time."

By now several others had picked up on the conversation. A bright looking kid in a blue gabardine suit interrupted: "Sunshine acid? Are you talking about LSD?"

- The Campaign Trail: More Fear and Loathing in Miami: Nixon Bites the Bomb, September 28, 1972, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson


'Now the others understood. A few laughed, but others muttered darkly, " You mean John Chancellor goes around putting LSD in people's drinks? He takes it himself?...He's a dope addict?..."

"Golly," said the girl. "That explains a lot, doesn't it?"

By this time I was having a hard time keeping a straight face. Those poor, ignorant young waterheads. Would they pass this weird revelation to their parents when they got back home to Middletown, Shaker Heights, and Orange County? Probably so, I thought. And then their parents would write letters to NBC, saying they'd learned from reliable sources that Chancellor was addicted to LSD-25 - supplied to him in great quantities, no doubt, by Communist agents - and demanding that he be jerked off the air immediately and locked up.

I was tempted to start babbling crazily about Walter Cronkite: that he was heavy into the white slavery trade - sending agents to South Vietnam to adopt orphan girls, then shipping them back to his farm in Quebec to be lobotomized and sold into brothels up and down the Eastern seaboard...'

- The Campaign Trail: More Fear and Loathing in Miami: Nixon Bites the Bomb, September 28, 1972, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson


'I recalled these things Ford had said, but I was not sure I'd heard Dick Tuck correctly - or if I'd really heard him at all. I held my right hand in front of my eyes, trying to remember if I'd eaten anything the night before to cause hallucinations. If so, my hand would appear to be transparent, and I would be able to see all the bones and blood vessels very clearly.

But my hand was not transparent. I moaned again, bringing Sandy in from the kitchen to find out what was wrong. "Did Tuck just call?" I asked.

She nodded: "He was almost hysterical. Ford just gave Nixon a full pardon."

I sat up quickly, groping around the bed for something to smash. "No!" I shouted. "That's impossible!"

She shook her head. "I heard it on the radio, too."

I stared at my hands again, feeling anger behind my eyes and noise coming up in my throat: "That stupid, lying bastard! Jesus! Who votes for these treacherous scumbags! You can't even trust the dumb ones! Look at Ford! He's too goddamn stupid to arrange a deal like that! Hell, he's almost too stupid to lie."

Sandy shrugged. "He gave Nixon all the tapes, too."'

- Fear and Loathing in Limbo: The Scum Also Rises, October 10, 1974, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson


'What finally cracked the Brown Buffalo was the bridge he refused to build between the self-serving elegance of his instincts and the self-destructive carnival of his reality. He was a Baptist missionary at a leper colony in Panama before he was a lawyer in Oakland and East L.A., or a radical-chic author in San Francisco and Beverly Hills...But whenever things got tense or when he had to work close to the bone, he was always a missionary. And that was the governing instinct that ruined him for anything else. He was a preacher in the courtroom, a preacher at the typewriter, and a flat-out awesome preacher when he cranked his head full of acid.

That's LSD-25, folks - a certified "dangerous drug" that is no longer fashionable, due to reasons of extreme and unnatural heaviness. The CIA was right about acid: some of their best and brightest operatives went over the side in the name of Top Secret research on a drug that was finally abandoned as a far too dangerous and unimaginable thing to be used as a public weapon. Not even the sacred minnock of "national security" could justify the hazards of playing with a thing too small to be seen and too big to control. The professional spook mentality was more comfortable with things like nerve gas and neutron bombs.

But not the Brown Buffalo - he ate LSD-25 with a relish that bordered on worship. When his brain felt bogged down in the mundane nuts-and-bolts horrors of the Law or some dead-end manuscript, he would simply take off in his hot rod Mustang for a week on the road and a few days of what he called "walking with the King." Oscar used acid like other lawyers use Valium - a distinctly unprofessional and occasionally nasty habit that shocked even the most liberal of his colleagues and frequently panicked his clients.'

- Fear & Loathing in the Graveyard of the Weird: The Banshee Screams for Buffalo Meat, December 15, 1977, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson


'When he came booming into a bar called the Daisy Duck in Aspen and announced he was the trouble we'd all been waiting for, he was definitely into the politics of confrontation - and on all fronts: in the bars or the courts or the streets, if necessary.

Oscar was not into serious street fighting, but he was hell on wheels in a bar brawl. Any combination of a two-hundred-fifty- pound Mexican and LSD-25 is a potentially terminal menace for anything it can reach - but when the alleged Mexican is in fact a profoundly angry Chicano lawyer with no fear at all of anything that walks on less than three legs and a de-facto suicidal conviction that we will die at the age of thirty-three - just like Jesus Christ - you have a serious piece of work on your hands. Especially if the bastard is already thirty-three and a half years old with a head full of Sandoz acid, a loaded .357 Magnum in his belt, a hatchet-wielding Chicano bodyguard at his elbow at all times, and a disconcerting habit of projectile-vomiting geysers of pure red blood off the front porch every thirty or forty minutes, or whenever his malignant ulcer can't handle any more raw tequila.

This was the Brown Buffalo in the full crazed flower of his prime - a man, indeed, for all seasons. And it was somewhere in the middle of his thirty-third year, in fact, when he came out to Colorado - with his faithful bodyguard, Frank - to rest for a while after his grueling campaign for sheriff of Los Angeles County, which he lost by a million or so votes. But in defeat, Oscar had managed to create an instant political base for himself in the vast Chicano barrio of East Los Angeles - where even the most conservative of the old-line "Mexican-Americans" were suddenly calling themselves "Chicanos" and getting their first taste of tear gas at "La Raza" demonstrations, which Oscar was quickly learning to use as a fire-and-brimstone forum to feature himself as the main spokesman for a mushrooming "Brown Power" movement that the LAPD called more dangerous than the Black Panthers.

Which was probably true, at that time - but in retrospect it sounds a bit different than it did back in 1969 when the sheriff was sending out fifteen or twenty helicopter sorties a night to scan the rooftops and backyards of the barrio with huge sweeping searchlights that drove Oscar and his people into fits of blind rage every time they got nailed in a pool of blazing white light with a joint in one hand and a machete in the other'

- Fear & Loathing in the Graveyard of the Weird: The Banshee Screams for Buffalo Meat, December 15, 1977, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson


'I was getting too nervous to continue without chemical assistance. I reached under my seat for my kit bag, which contained five or six capsules of Black Acid. Wonderful, I thought. This is just what I need. I ate one and went back to pondering the map. There was a place called Deeth, just ahead, where a faintly marked side road appeared to wander uphill through the mountains and down along a jagged ridge into Jackpot from behind. Good, I thought, this is it. We could sneak in to Jackpot by dawn.

Just then I felt a blow on the side of my head as the Judge came awake with a screech, flailing his arms around him like he was coming out of a nightmare. "What's happening, goddamn it?" he said. "Where are we? They're after us." He was jabbering in a foreign language that quickly lapsed into English as he tried to aim the gun. "Oh, God," he screamed. "They're right on top of us. Get moving, goddamn it. I'll kill every bastard I see."

He was coming out of a nightmare. I grabbed him by the neck and put him in a headlock until he went limp. I pulled him back up in the seat and handed him a spansule of acid. "Here, Judge, take this," I said. "It'll calm you down."

He swallowed the pill and said nothing as I turned onto the highway and stood heavily on the accelerator. We were up to 115 when a green exit sign that said "Deeth No Services" loomed suddenly out of the rain just in front of us. I swerved hard to the right and tried to hang on. But it was no use. I remember the sound of the Judge screaming as we lost control and went into a full 360-degree curl and then backward at seventy-five or eighty through a fence and into a pasture.

For some reason the near-fatal accident had a calming effect on the Judge. Or maybe it was the acid. I didn't care one way or the other after I took the gun from his hand. He gave it up without a fight.'

- Fear and Loathing in Elko, January 23, 1992, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson


'I will miss Tim Leary - not for his wisdom or his beauty or his warped lust for combat or because of his wealth or his power or his drugs, but mainly because I won't hear his laughing voice on my midnight telephone anymore. Tim usually called around 2. It was his habit - one of many that we shared, and he knew that I would be awake.

Tim and I kept the same hours. He believed, as I do, that "after midnight, all things are possible."

Just last week he called me on the phone at two-thirty in the morning and said he was moving to a ranch in Nicaragua in a few days and would fax me the telephone number. Which he did. And I think he also faxed it to Dr. Kasey.

Indeed. There are many rooms in the mansion. And Tim was familiar with most of them. We will never know the range of his fiendish vision, or the many lives he was sucked into by his savage and unnatural passions.

We sometimes disagreed, but in the end we made our peace. Tim was a Chieftain. He Stomped on the Terra, and he left his elegant hoof prints on all our lives.

He is forgotten now but not gone. We will see him soon enough. Our tribe is now smaller by one. Our circle is one link shorter. And there is one more name in the honor list of pure warriors who saw the great light and leapt for it.'

- Memo from the National Affairs Desk. To: Jann S. Wenner, August 8, 1996, Fear and Loathing at the Rolling Stone, The Essential Writing of Hunter S. Thompson